Tropine Chemical Properties

Melting point:

50-60 °C(lit.)

Boiling point:

233 °C(lit.)

Density 

1.045 g/mL at 25 °C(lit.)

refractive index 

1.4811 (estimate)

Flash point:

232-234°C

storage temp. 

Inert atmosphere,2-8°C

solubility 

H₂O: 0.1 g/mL, clear

form 

Crystalline Powder

pka

3.80(at 15℃)

color 

White to slightly yellow

PH

12 (100g/l, H2O, 20℃)

Water Solubility 

100 g/L (20 ºC)

Sensitive 

Hygroscopic

Merck 

14,9781

BRN 

80188

InChIKey

CYHOMWAPJJPNMW-JIGDXULJSA-N

LogP

-0.100 (est)

CAS DataBase Reference

120-29-6(CAS DataBase Reference)

NIST Chemistry Reference

Tropine(120-29-6)

EPA Substance Registry System

8-Azabicyclo[3.2.1]octan-3-ol, 8-methyl-, (3-endo)- (120-29-6)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

26/28-20/22

Safety Statements 

22-24/25

RIDADR 

1544

WGK Germany 

3

RTECS 

YM3875000

F 

3

Hazard Note 

Irritant

TSCA 

Yes

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

29399990

MSDS

• Language:English Provider:Tropine
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Tropine Usage And Synthesis

Chemical Properties

white to slightly yellow crystalline powder

Uses

Tropine as an oxidative product of Tropane, used to synthesize alkaloid derivatives. Benzatropine and etybenzatropine are derivatives of tropine. It is also a building block of atropine, an anticholinergic drug prototypical of the muscarinic antagonist class.

Uses

Tropine is an oxidative product of Tropane, used to synthesize alkaloid derivatives.

Definition

ChEBI: A derivative of tropane having a hydroxy group at the 3-position.

Purification Methods

Distil 3-tropanol in steam and crystallise it from Et2O or toluene/pet ether. It sublimes at 60o/0.1mm. Hygroscopic. The hydrochloride has m 280o (from EtOH/Et2O). [Beilstein 21 H 16, 21 I 197, 21 II 17, 21 III/IV 168, 21/1 V 219.]

Tropine(120-29-6)Related Product Information

• Thiophanate-methyl
• beta-Methyl vinyl phosphate (MAP)
• Hexamethyldisilazane
• METSULFURON METHYL
• N-Methyl-2-pyrrolidone
• Octamethylcyclotetrasilazane
• Tropicamide
• Methyl salicylate
• Kresoxim-methyl
• Tribenuron methyl
• Sodium bis(trimethylsilyl)amide
• Methyl acetate
• Tolyltriazole
• Tropine-3-thiol hydrochloride,Tropine-3-thiol Hcl
• Tropine-3-thiol
• Tropinone
• Indole-3-carboxylic acid
• Terpineol