1-Ethynyl-1-cyclohexanol Chemical Properties

Melting point:

30-33 °C(lit.)

Boiling point:

180 °C(lit.)

Density 

0.967 g/mL at 25 °C(lit.)

vapor pressure 

<1 mm Hg ( 20 °C)

refractive index 

1.481-1.484

Flash point:

163 °F

storage temp. 

Store below +30°C.

solubility 

10 g/L (20°C)

form 

Liquid After Melting

pka

13.34±0.20(Predicted)

color 

Clear colorless to light yellow

PH

7 (1g/l, H2O, 20℃)

explosive limit

1.3-8.7%(V)

Water Solubility 

10 g/L (20 ºC)

BRN 

471404

InChIKey

QYLFHLNFIHBCPR-UHFFFAOYSA-N

LogP

1.49 at 25℃

CAS DataBase Reference

78-27-3(CAS DataBase Reference)

NIST Chemistry Reference

Cyclohexanol, 1-ethynyl-(78-27-3)

EPA Substance Registry System

Cyclohexanol, 1-ethynyl- (78-27-3)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

21/22-36-36/37/38-20/21/22-36/38

Safety Statements 

36/37-36/37/39-26-36-22

RIDADR 

UN 2811 6.1/PG 3

WGK Germany 

1

RTECS 

GV9100000

Autoignition Temperature

365 °C

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

III

HS Code 

29061900

Toxicity

LD50 orally in Rabbit: 583 mg/kg LD50 dermal Rabbit 973 mg/kg

MSDS

• Language:English Provider:1-Ethynylcyclohexanol
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

1-Ethynyl-1-cyclohexanol Usage And Synthesis

Chemical Properties

Colorless liquid

Uses

Stabilization of chlorinated organic compounds, intermediate, corrosion inhibitor for mineral acids, medicine (sedative).

Uses

1-Ethynyl-1-cyclohexanol (ECHO) can undergo acetylation in the presence of a catalytic amount of ruthenium chloride at room temperature. It can be used to synthesize novel organotellurium(IV) compounds with potent inhibitory activity towards Cathepsin B. The polymerization of ECHO by transition metal catalysts leads to the formation of poly(ECHO). It can also react with transition metal hydride complexes to form vinyl derivatives by inserting into the M-H bonds.

Synthesis Reference(s)

Organic Syntheses, Coll. Vol. 3, p. 416, 1955
Synthetic Communications, 18, p. 131, 1988 DOI: 10.1080/00397918808077336

Flammability and Explosibility

Non flammable

1-Ethynyl-1-cyclohexanol(78-27-3)Related Product Information

• Cyclohexylbenzene
• 1-Methylcyclohexanol
• Cyclohexanol
• Molasses
• Cyclohexylamine
• 1-BUTEN-3-YNE
• Trimethylsilylacetylene
• Cyclohexanone
• Cyclohexanemethanol
• ETHYLENE
• Benzofluorfen
• Ethylene glycol
• 1-(PHENYLETHYNYL)-1-CYCLOHEXANOL
• ETHINAMATE
• 1,4-BIS(1-HYDROXYCYCLOHEXYL)-1,3-BUTADIYNE
• 1-[2-(1-HYDROXYCYCLOHEXYL)-1-ETHYNYL]-1-CYCLOHEXANOL
• mociprazine
• Terciprazine