STARBURST(R) (PAMAM) DENDRIMER, GENERATION 1 Chemical Properties

Boiling point:

64.7 °C

Density 

0.82 g/mL at 25 °C

refractive index 

n20/D 1.362

Flash point:

52 °F

storage temp. 

2-8°C

solubility 

Water: Soluble

form 

20 wt.% in methanol

color 

Colorless to light yellow

InChIKey

QVWIZHOFYGKROL-UHFFFAOYSA-N

SMILES

C(NCCN)(=O)CCN(CCC(NCCN)=O)CCNC(=O)CCN(CCC(NCCN(CCC(NCCN)=O)CCC(NCCN)=O)=O)CCN(CCC(NCCN(CCC(NCCN)=O)CCC(NCCN)=O)=O)CCC(=O)NCCN(CCC(NCCN)=O)CCC(NCCN)=O

Safety Information

Hazard Codes 

F,T

Risk Statements 

11-23/24/25-39/23/24/25-36/37/38

Safety Statements 

7-16-23-45-36/37-26

RIDADR 

UN 1230 3/PG 2

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

STARBURST(R) (PAMAM) DENDRIMER, GENERATION 1 Usage And Synthesis

Uses

Starburst 1st Generation (PAMAM G1.0) is a Polyamidoamine (HY-164657; PAMAM) dendrimer with amine termini that has been used as a drug delivery system in vitro. Starburst 1st Generation conjugated to di-n-dodecylamine and encapsulating 5-Fluorouracil (HY-90006) increase the solubility of 5-Fluorouracil and are cytotoxic to AGS gastric adenocarcinoma cells[1].

References

[1] Ender Sarigul, et al. Polyamidoamine Dendron-Bearing Lipids as Drug-Delivery Excipients. Molecules. 2022 Nov 13;27(22):7817. DOI:10.3390/molecules27227817
[2] TISHA C. KING HEIDEN . Developmental toxicity of low generation PAMAM dendrimers in zebrafish[J]. Toxicology and applied pharmacology, 2007, 225 1: Pages 70-79. DOI: 10.1016/j.taap.2007.07.009
[3] XIAOYE ZHANG. Preparation of PVDF/Hyperbranched-Nano-Palygorskite Composite Membrane for Efficient Removal of Heavy Metal Ions.[J]. Polymers, 2019, 11 1. DOI: 10.3390/polym11010156

STARBURST(R) (PAMAM) DENDRIMER, GENERATION 1(142986-44-5)Related Product Information

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