Polyinosinic-polycytidylic acid sodium salt Chemical Properties

storage temp. 

−20°C

solubility 

H2O: soluble10mg/mL

form 

lyophilized powder

color 

White to off-white

Water Solubility 

Water : 10 mg/mL (Need ultrasonic and warming)

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

RTECS 

TR0175000

MSDS

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Polyinosinic-polycytidylic acid sodium salt Usage And Synthesis

Uses

Polyinosinic Acid & Polycytidylic Acid Sodium Salt (double-stranded) is a TLR3 (Toll-like receptor 3) agonist.

Uses

TLR3 recognizes double-stranded RNA and is a major effector of the immune response against viral pathogens. Polyinosinic–polycytidylic acid sodium salt is a double-stranded homopolymer used as a model RNA to study cell signaling at the level of TLR3. Poly(IC) is a TRIF-dependent toll-like receptor-3 (TLR3) ligand.

Biological Activity

Polyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid sodium can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid sodium can directly trigger cancer cells to undergo apoptosis.

storage

Store at -20°C

Polyinosinic-polycytidylic acid sodium salt(42424-50-0)Related Product Information

• METHYL ISOCYANOACETATE
• SALCOMINE
• TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III)
• TERT-BUTYL ISOCYANIDE
• Ethyl isocyanoacetate
• COBALT(II) ACETYLACETONATE
• PHENYLSELENOL
• TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III)
• Ferric acetylacetonate
• Benzyl isocyanide
• Aluminum acetylacetonate
• Tris(2,4-pentanedionato)chroMiuM(III)
• DICHLORO(ETHYLENEDIAMINE)PLATINUM(II)
• Tosylmethyl isocyanide
• N-BUTYLISOCYANIDE
• Cupric acetylacetonate
• 2,4-PENTANEDIONE, SILVER DERIVATIVE
• Polyinosinic acid