5-AMINO-3-BROMO (1H)INDAZOLE Chemical Properties

Boiling point:

431.3±25.0 °C(Predicted)

Density 

1.867±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

12.34±0.40(Predicted)

Appearance

Light brown to brown Solid

Safety Information

RIDADR 

UN2811

HS Code 

2933998090

5-AMINO-3-BROMO (1H)INDAZOLE Usage And Synthesis

Uses

3-Bromo-1H-indazol-5-amine acts as a reagent for the preparation of Polycyclic indazole derivatives that are ERK inhibitors and their use in the treatment and prevention of cancer, anilino quinazolines as antitumor agents.

Synthesis

General procedure for the synthesis of 3-bromo-5-aminoindazole from 3-bromo-5-nitroindazole: Tin(II) chloride dihydrate (100.4 g, 44.62 mmol) was added batchwise to a solution of 3-bromo-5-nitro-1H-indazole (18.0 g, 7.43 mmol) in ethanol (400 mL) at 0°C. The reaction was carried out by stirring for 14 h at 80°C. The reaction was carried out in the same way that the reaction was carried out in the same way that the reaction was carried out in the same manner. The reaction mixture was then stirred at 80 °C for 14 hours. Upon completion of the reaction, the product was isolated and purified by standard methods, resulting in 3-bromo-1H-indazol-5-amine (14.5 g, 92%) as a light brown solid.

References

[1] Patent: WO2016/89977, 2016, A1. Location in patent: Paragraph 00193
[2] Patent: EP1403255, 2004, A1. Location in patent: Page 133
[3] Patent: WO2007/70398, 2007, A1. Location in patent: Page/Page column 193

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