ALPHA-HYDROXY-GAMMA-BUTYROLACTONE Chemical Properties

Boiling point:

133 °C/10 mmHg (lit.)

Density 

1.309 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.468(lit.)

Flash point:

>230 °F

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Chloroform (Sparingly), Methanol (Slightly)

pka

13.07±0.20(Predicted)

form 

Viscous Liquid

color 

Clear colorless to yellow

BRN 

80587

InChIKey

FWIBCWKHNZBDLS-UHFFFAOYSA-N

LogP

-1.830 (est)

CAS DataBase Reference

19444-84-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

23-24/25-36-26

WGK Germany 

3

F 

3-10

HS Code 

29322090

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich

ALPHA-HYDROXY-GAMMA-BUTYROLACTONE Usage And Synthesis

Chemical Properties

clear colorless to yellow viscous liquid

Uses

α-Hydroxy-γ-butyrolactone may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis. 1 It may be employed as starting reagent in the synthesis of enantiomerically pure orthogonally protected δ-azaproline, via Mitsunobu reaction.

Uses

α-Hydroxy-γ-butyrolactone may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis. It may be employed as starting reagent in the synthesis of enantiomerically pure orthogonally protected δ-azaproline, via Mitsunobu reaction.

General Description

α-Hydroxy-γ-butyrolactone is a 5-membered cyclic ester. It was obtained via tin-conversion of biomass-derived 1,3-dihydroxyacetone (DHA) and formaldehyde.

Purification Methods

It has been purified by repeated fractionation and forms a colourless liquid. It has to be distilled at high vacuum; otherwise it will dehydrate. The acetox

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