TRIETHYL 2-PHOSPHONOPROPIONATE Chemical Properties

Melting point:

161-164°

Boiling point:

143-144 °C12 mm Hg(lit.)

Density 

1.111 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.431(lit.)

Flash point:

192 °F

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Miscible with chloroform and methanol.

form 

Liquid

color 

Clear colorless

Specific Gravity

1.111

BRN 

1786994

InChIKey

BVSRWCMAJISCTD-UHFFFAOYSA-N

CAS DataBase Reference

3699-66-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38-38-37-36

Safety Statements 

23-24/25-36-26-39-37

RIDADR 

1993

WGK Germany 

3

F 

10

Hazard Note 

Irritant

HS Code 

29319019

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

TRIETHYL 2-PHOSPHONOPROPIONATE Usage And Synthesis

Chemical Properties

CLEAR COLOURLESS LIQUID

Uses

Triethyl 2-Phosphonopropionate is used in studies involving insecticides and their efficacy on various bacterium. Also act as inhibitors of Epstein-Bar virus transmission and infections.

Uses

Triethyl 2-phosphonopropionate is used as a reactant in intramolecular conjugate addition for the synthesis of floresolide B, enantioselective synthesis of spiroindane di-methyl acetic acid and in stereo selective intramolecular Diels-Alder reactions. It plays an important role in Horner-Wadsworth-Emmons reactions and chemoenzymatic one-pot synthesis of gamma-butyrolactones. It is also used in the preparation of 3-[2]furyl-2-methyl-acrylic acid ethyl ester by reacting with furfural.

Purification Methods

Purify it by fractional distillation with high reflux ratio, preferably using a spinning band column. [Kosolapoff & Powell J Am Chem Soc 72 4198 1950, Kresze et al. Justus Liebigs Ann Chem 756 112 1972, Beilstein 4 IV 3617.]

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