3,4-Epoxytetrahydrofuran Chemical Properties

Boiling point:

44°C 10mm

Density 

1.237

refractive index 

1.445-1.449

Flash point:

>38℃

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

form 

Liquid

color 

Clear yellow

Water Solubility 

MODERATELY SOLUBLE

InChI

InChI=1S/C4H6O2/c1-3-4(6-3)2-5-1/h3-4H,1-2H2

InChIKey

AIUTZIYTEUMXGG-UHFFFAOYSA-N

SMILES

C12C(O1)COC2

CAS DataBase Reference

285-69-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38-10

Safety Statements 

36/37/39-26-23-16-36/37/38

RIDADR 

1993

Hazard Note 

Irritant

HazardClass 

3

PackingGroup 

Ⅲ

HS Code 

29321900

MSDS

• Language:English Provider:3,6-Dioxabicyclo[3.1.0]hexane
• Language:English Provider:ACROS

3,4-Epoxytetrahydrofuran Usage And Synthesis

Uses

3,6-Dioxabicyclo[3.1.0]hexane was a reagent used in making various degradable polymers from epoxides using a versatile dinuclear chromium catalyst.

Chemical Properties

clear yellow liquid

Synthesis

Step 1: 85% m-chloroperoxybenzoic acid (mCPBA) (18.86 g, 0.093 mol) was slowly added to 150 mL of dichloromethane solution containing 2,5-dihydrofuran (5.04 g, 0.072 mol) at 0°C in an ice-water bath. The reaction mixture was stirred at room temperature for 48 hours. After completion of the reaction, the precipitate was removed by filtration. The filtrate was washed sequentially with saturated aqueous sodium bicarbonate, water and brine. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give a mixture of white solid and yellow oil (5.24 g, 84.6% yield).

References

[1] Patent: WO2008/33562, 2008, A2. Location in patent: Page/Page column 53
[2] Patent: US2009/76005, 2009, A1. Location in patent: Page/Page column 23
[3] Bioorganic and Medicinal Chemistry, 2006, vol. 14, # 24, p. 8467 - 8487
[4] Patent: US5374416, 1994, A
[5] Patent: US2009/30212, 2009, A1. Location in patent: Page/Page column 15-16

3,4-Epoxytetrahydrofuran(285-69-8)Related Product Information

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• POLY(TETRAHYDROFURAN) STANDARD 15000
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• Actein
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• 4,9,11-trioxatetracyclo[5.3.1.0(2,6).0(8,10)]undecan-3-one
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• 26-DEOXYCIMICIFUGOSIDE
• (2R,4R,5R)-2-ALLYLOXYMETHYL-4-DIMETHOXYMETHYL-3,6-DIOXA-BICYCLO[3.1.0]HEXANE
• lophotoxin
• POLY(TETRAHYDROFURAN) STANDARD 20000
• 3,4-Epoxytetrahydrofuran
• 4,5-DIMETHYL-5-HYDROXY-3-(METHOXYCARBONYL)-3,4-EPOXY-GAMMA-BUTYROLACTONE
• METHYL-2,3-ANHYDRO-5-O-(4-PHENYLBENZOYL)-BETA-D-LYXOFURANOSIDE
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