1,2-Phenylenediacetic acid Chemical Properties

Melting point:

150-152 °C (lit.)

Boiling point:

290.62°C (rough estimate)

Density 

1.2534 (rough estimate)

refractive index 

1.5430 (estimate)

storage temp. 

Sealed in dry,Room Temperature

form 

Needle-Like Crystalline Powder

pka

3.90±0.10(Predicted)

color 

Beige to beige-brown

BRN 

2616747

InChI

InChI=1S/C10H10O4/c11-9(12)5-7-3-1-2-4-8(7)6-10(13)14/h1-4H,5-6H2,(H,11,12)(H,13,14)

InChIKey

MMEDJBFVJUFIDD-UHFFFAOYSA-N

SMILES

C1(CC(O)=O)=CC=CC=C1CC(O)=O

CAS DataBase Reference

7500-53-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39

WGK Germany 

3

HS Code 

29173990

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

1,2-Phenylenediacetic acid Usage And Synthesis

Chemical Properties

beige to beige-brown needle-like crystalline

Uses

1,2-Phenylenediacetic Acid has been used in the preparation of nanomolar inhibitors of cancer-relevant transcription factor STAT5b.

General Description

A coordination polymer with 1,2-Phenylenediacetic acid was synthesized and characterized by single crystal X-ray diffraction.

Synthesis

The general procedure for the synthesis of 2,2'-(1,2-phenylene)diacetic acid from 1,2-phenylenediacetonitrile was as follows: 1,2-phenylenediacetonitrile (5.0 g) was dissolved in 50 mL of concentrated hydrochloric acid and heated and refluxed for 3 hours. After the reaction was completed, 30 mL of water was added and heating was continued overnight. The reaction mixture was cooled to room temperature and washed with ether. Subsequently, the organic layer was extracted twice with aqueous sodium carbonate. The aqueous layers were combined, acidified to pH 2-3 with hydrochloric acid and extracted with ether. The organic phase was dried with anhydrous magnesium sulfate, filtered and concentrated to give 2,2'-(1,2-phenylene)diacetic acid as a light yellow solid in 56% yield with a melting point of 123-125 °C. The product was confirmed by 1H NMR (250 MHz, DMSO-d6): δ 3.58 (s, 4H), 7.20 (s, 4H), 12.34 (br s, 2H); 13C NMR (63 MHz, DMSO-d6): δ 37.1 (2C), 126.8 (2C), 130.6 (2C), 134.1 (2C), 172.4 (2C).

References

[1] Patent: WO2011/41349, 2011, A1. Location in patent: Page/Page column 19-20
[2] Chemische Berichte, 1884, vol. 17, p. 447
[3] Journal of the Chemical Society, 1907, vol. 91, p. 176
[4] Journal of the Chemical Society, 1923, vol. 123, p. 2075
[5] Recueil des Travaux Chimiques des Pays-Bas, 1923, vol. 42, p. 412

1,2-Phenylenediacetic acid(7500-53-0)Related Product Information

• Stearic acid
• Allyl phenoxyacetate
• 2-Hydroxyphenylacetic acid
• Methyl phenylacetate
• Ethyl phenylacetate
• Hyaluronic acid
• Phthalic acid
• Bis(2-ethylhexyl) phthalate
• Methyl 2,2-dimethylphenylacetate
• Ethyl 2-(Chlorosulfonyl)acetate
• 4-Hydroxyphenylacetic acid
• Potassium hydrogen phthalate
• 4-Nitrophenylacetic acid
• Phenoxyacetic acid
• o-Phenylenediamine
• Folic acid
• Citric acid
• Dimethyl phthalate