2-Chloro-6-fluorobenzyl chloride Chemical Properties

Melting point:

7 °C

Boiling point:

208-210 °C

Density 

1.401 g/mL at 25 °C (lit.)

vapor pressure 

83Pa at 40℃

refractive index 

n20/D 1.537(lit.)

Flash point:

200 °F

storage temp. 

Inert atmosphere,Room Temperature

form 

clear liquid

Specific Gravity

1.401

color 

Colorless to Almost colorless

Sensitive 

Lachrymatory

BRN 

386840

InChI

1S/C7H5Cl2F/c8-4-5-6(9)2-1-3-7(5)10/h1-3H,4H2

InChIKey

MJGOLNNLNQQIHR-UHFFFAOYSA-N

SMILES

Fc1cccc(Cl)c1CCl

LogP

3.64

CAS DataBase Reference

55117-15-2(CAS DataBase Reference)

NIST Chemistry Reference

2-Chloro-6-fluorobenzyl chloride(55117-15-2)

EPA Substance Registry System

Benzene, 1-chloro-2-(chloromethyl)-3-fluoro- (55117-15-2)

Safety Information

Hazard Codes 

C,Xi,N

Risk Statements 

34-51/53

Safety Statements 

26-36/37/39-45-61

RIDADR 

UN 3265 8/PG 2

WGK Germany 

3

Hazard Note 

Corrosive/Lachrymatory

TSCA 

TSCA listed

HazardClass 

8

PackingGroup 

III

HS Code 

29039990

Storage Class

8A - Combustible corrosive hazardous materials

Hazard Classifications

Skin Corr. 1B

MSDS

• Language:English Provider:1-Chloro-2-(chloromethyl)-3-fluorobenzene
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2-Chloro-6-fluorobenzyl chloride Usage And Synthesis

Chemical Properties

clear colorless liquid

Uses

2-Chloro-6-fluorobenzyl chloride was used:

• as alkylating reagent during the synthesis of 3-benzylsulfanyl derivatives of 1,2,4-triazole and 4-methyl-1,2,4-triazole
• in the preparataion of 2-chloro-6-fluorobenzylamine, required for the synthesis of 9-substituted adenine
• in the preparation of aprinocid via reaction with adenine

Synthesis

Add 250 g of 2-chloro-6-fluorotoluene and 0.5 ml of phosphorus trichloride (the addition of phosphorus trichloride in this step can improve the quality of the product) to a 500 ml four-necked glass reaction flask equipped with a reflux condenser tube, an off-gas absorption device and a thermometer, and pass the chlorine gas under the irradiation of a metal halide lamp and keep it under the 180 Chlorine gas was passed under the condition of ?? to obtain 2-chloro-6-fluorobenzyl chloride. Detect the content of 2-chloro-6-fluorobenzyl chloride in the liquid phase of the reaction bottle by gas chromatography, and when the content of 2-chloro-6-fluorobenzyl chloride is detected to be less than 0.5%, stop passing the chlorine gas, and simultaneously When the content of 2-chloro-6-fluorobenzyl chloride is detected to be less than 0.5%, stop passing chlorine gas, and at the same time, pass nitrogen into the reaction bottle to remove the unreacted chlorine in the bottle.

2-Chloro-6-fluorobenzyl chloride(55117-15-2)Related Product Information

• 4-Chlorobenzyl chloride
• Benzyl chloroformate
• 2-Methylbenzyl chloride
• Calcium chloride
• alpha-Chloro-o-fluorotoluene
• Polyvinyl chloride
• 2-Chlorobenzyl chloride
• Sodium chloride
• 3-Chlorobenzyl chloride
• Choline chloride
• Ammonium chloride
• 4-Fluorobenzyl chloride
• 4-Methoxybenzylchloride
• Potassium chloride
• Difluorochloromethane
• Methylene Chloride
• 2-CHLORO-6-FLUOROBENZOTRICHLORIDE
• 6-CHLORO-2-FLUORO-3-METHYLBENZOYL CHLORIDE