OLSALAZINE Chemical Properties

Melting point:

>300 °C(Solv: acetic acid (64-19-7); water (7732-18-5))

Boiling point:

443.29°C (rough estimate)

Density 

1.3578 (rough estimate)

refractive index 

1.6500 (estimate)

solubility 

DMSO: soluble
Methanol: soluble

form 

Solid

pka

2.40±0.10(Predicted)

color 

Light yellow to yellow

Water Solubility 

11.49ug/L(25 ºC)

CAS DataBase Reference

15722-48-2(CAS DataBase Reference)

OLSALAZINE Usage And Synthesis

Uses

Anti-inflammatory (gastrointestinal).

Definition

ChEBI: An azobenzene that consists of two molecules of 4-aminosalicylic acid joined by an azo linkage. A prodrug for mesalazine, an anti-inflammatory drug, it is used (as the disodium salt) in the treatment of inflammatory bowel disease.

Indications

Olsalazine is approved for maintenance of remission of ulcerative colitis, but a commonly reported side effect is a paradoxical increase in diarrhea. The U. S. Food and Drug Administration (FDA) has approved balsalazide disodium (Colazal) as a treatment of mild to moderately active ulcerative colitis.

brand name

Dipentum (UCB).

Mechanism of action

Olsalazine is approved for maintenance of remission of ulcerative colitis, but a commonly reported side effect is a paradoxical increase in diarrhea. The U. S. Food and Drug Administration (FDA) has approved balsalazide disodium (Colazal) as a treatment of mild to moderately active ulcerative colitis.

Veterinary Drugs and Treatments

Olsalazine is used for treatment of dogs with chronic colitis that either cannot tolerate the adverse effects associated with sulfasalazine or the response to sulfasalazine has been ineffective.

References

[1] S. NUGENT. Intestinal luminal pH in inflammatory bowel disease: possible determinants and implications for therapy with aminosalicylates and other drugs[J]. Gut, 2001, 48 1: 571-577. DOI: 10.1136/gut.48.4.571
[2] R. PAMUKCU E C S Hanauer. Effect of disodium azodisalicylate on electrolyte transport in rabbit ileum and colon in vitro. Comparison with sulfasalazine and 5-aminosalicylic acid.[J]. Gastroenterology, 1988, 95 4 1: 975-981. DOI: 10.5555/uri:pii:0016508588901722
[3] A Q MOHSEN. Effects of olsalazine in the jejunum of the rat.[J]. Gut, 1987, 28 3: 346-352. DOI: 10.1136/gut.28.3.346
[4] S MURTHY. The efficacy of BAY y 1015 in dextran sulfate model of mouse colitis.[J]. Inflammation Research, 1997, 46 6: 224-233. DOI: 10.1007/s000110050177
[5] YANFEN NIU . Old drug, new indication: Olsalazine sodium reduced serum uric acid levels in mice via inhibiting xanthine oxidoreductase activity[J]. Journal of pharmacological sciences, 2017, 135 3: Pages 114-120. DOI: 10.1016/j.jphs.2017.10.007

OLSALAZINE(15722-48-2)Related Product Information

• D-Glucurone
• Anastrozole
• Olsalazine sodium EP Impurity B
• Omeprazole magnesium
• Magnesium trisilicate
• 6-Mercaptopurine
• 5-Aminosalicylic acid
• 3,3'-DIMETHYLAZOBENZENE
• OLSALAZINE
• Olsalazine sodium
• OLSALAZINE SODIUM FOR PERFORMANCE TEST
• olsalazine-O-sulfate
• 3,3'-AZODIBENZOIC ACID
• Sodium olsalazine
• OLSALAZINE HCL
• Olsalazine(Dipentum)