OLSALAZINE
OLSALAZINE Basic information
- Product Name:
- OLSALAZINE
- Synonyms:
-
- Ph-CJ-91B
- 4,4'-Dihydroxyazobenzene-3,3'-dicarboxylic acid
- 5,5'-Azodisalicylic acid
- 3,3'-(1,2-diazenediyl)bis[6-hydroxy-Benzoic acid
- OLSALAZINE
- 3,3’-azobis(6-hydroxy-benzoicaci
- 3,3’-azobis(6-hydroxybenzoicacid)
- 5,5’-azobis(salicylicacid)
- CAS:
- 15722-48-2
- MF:
- C14H10N2O6
- MW:
- 302.24
- EINECS:
- 605-089-5
- Mol File:
- 15722-48-2.mol
OLSALAZINE Chemical Properties
- Melting point:
- >300 °C(Solv: acetic acid (64-19-7); water (7732-18-5))
- Boiling point:
- 443.29°C (rough estimate)
- Density
- 1.3578 (rough estimate)
- refractive index
- 1.6500 (estimate)
- pka
- 2.40±0.10(Predicted)
- Water Solubility
- 11.49ug/L(25 ºC)
- CAS DataBase Reference
- 15722-48-2(CAS DataBase Reference)
OLSALAZINE Usage And Synthesis
Uses
Anti-inflammatory (gastrointestinal).
Definition
ChEBI: An azobenzene that consists of two molecules of 4-aminosalicylic acid joined by an azo linkage. A prodrug for mesalazine, an anti-inflammatory drug, it is used (as the disodium salt) in the treatment of inflammatory bowel disease.
Indications
Olsalazine is approved for maintenance of remission of ulcerative colitis, but a commonly reported side effect is a paradoxical increase in diarrhea. The U. S. Food and Drug Administration (FDA) has approved balsalazide disodium (Colazal) as a treatment of mild to moderately active ulcerative colitis.
brand name
Dipentum (UCB).
Mechanism of action
Olsalazine is approved for maintenance of remission of ulcerative colitis, but a commonly reported side effect is a paradoxical increase in diarrhea. The U. S. Food and Drug Administration (FDA) has approved balsalazide disodium (Colazal) as a treatment of mild to moderately active ulcerative colitis.
Veterinary Drugs and Treatments
Olsalazine is used for treatment of dogs with chronic colitis that either cannot tolerate the adverse effects associated with sulfasalazine or the response to sulfasalazine has been ineffective.
OLSALAZINE Preparation Products And Raw materials
Raw materials
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OLSALAZINE(15722-48-2)Related Product Information
- D-Glucurone
- Anastrozole
- Olsalazine sodium EP Impurity B
- Omeprazole magnesium
- Magnesium trisilicate
- 6-Mercaptopurine
- 5-Aminosalicylic acid
- 3,3'-DIMETHYLAZOBENZENE
- OLSALAZINE
- Olsalazine sodium
- OLSALAZINE SODIUM FOR PERFORMANCE TEST
- olsalazine-O-sulfate
- 3,3'-AZODIBENZOIC ACID
- Sodium olsalazine
- OLSALAZINE HCL
- Olsalazine(Dipentum)