5-Pyrimidinemethanol Chemical Properties

Melting point:

51-52 °C

Boiling point:

250.8±15.0 °C(Predicted)

Density 

1.227±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

solid

pka

13.43±0.10(Predicted)

color 

Yellow

CAS DataBase Reference

25193-95-7(CAS DataBase Reference)

Safety Information

HS Code 

2933599590

5-Pyrimidinemethanol Usage And Synthesis

Uses

5-?Pyrimidinemethanol is a reagent used in the synthesis of melanin-concentrating hormone receptor 1 antagonists.Also used in the preparation of annulated 5-aryl-substituted pyridines.

Synthesis

Step 3. Synthesis of 5-pyrimidinemethanol. 5-Pyrimidinecarboxaldehyde (2 g, 18.50 mmol, 1.00 eq.) and sodium borohydride (2 g) were dissolved in methanol (100 mL) and the reaction was stirred for 30 min at 0-10 °C. Upon completion of the reaction, the solvent was removed by vacuum concentration and the resulting residue was purified by silica gel column chromatography with dichloromethane/methanol (50:1, v/v) as eluent to give 1.2 g (59% yield) of the target compound 5-pyrimidine methanol as a light yellow solid. Mass spectrometry result: m/z = 111.0 [M + H]+.

References

[1] Patent: WO2013/130935, 2013, A1. Location in patent: Paragraph 0218
[2] Patent: WO2013/19621, 2013, A1. Location in patent: Page/Page column 41
[3] Journal of Organic Chemistry, 2000, vol. 65, # 26, p. 9261 - 9264
[4] Patent: WO2009/45381, 2009, A1. Location in patent: Page/Page column 29-30
[5] Patent: WO2009/45386, 2009, A1. Location in patent: Page/Page column 32-33

5-Pyrimidinemethanol(25193-95-7)Related Product Information

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