ChemicalBook > Product Catalog > Pharmaceutical intermediates > Bulk Drug Intermediates > (5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester
(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester
(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester Basic information
- Product Name:
- (5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester
- Synonyms:
-
- Posaconazole Impurity 53
- ((3S,5R)-5-((1H-1,2,4-triazol-1-yl)Methyl)-5-(2,4-difluorophenyl)-tetrahydrofuran-3-yl)Methyl 4-Methylbenzenesulfonate
- Posaconazole InterMediates
- 2,5-Anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[[(4-Methylphenyl)sulfonyl]oxy]Methyl]-1-(1H-1,2,4-triazol-1-yl)-D-threo-pentitol
- (5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)Methyltetrahydrofuran-3-ylMethyl ester- (POA)
- (5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4
- Toluene-4-sulfonica cid 5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylMethyl-tetrahydro-furan-3-ylMethyl ester
- ((3R,5R)-5-((1H-1,2,4-triazol-1-yl)Methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)Methyl 4-Methylbenzenesulfonate
- CAS:
- 149809-43-8
- MF:
- C21H21F2N3O4S
- MW:
- 449.47
- EINECS:
- 1308068-626-2
- Product Categories:
-
- Aromatics
- Chiral Reagents
- Intermediates
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 149809-43-8.mol
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(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester Chemical Properties
- Melting point:
- 100-102°C
- Boiling point:
- 608.1±65.0 °C(Predicted)
- Density
- 1.40
- storage temp.
- -20°C Freezer, Under Inert Atmosphere
- solubility
- slightly sol. in Chloroform
- form
- powder to crystal
- pka
- 2.75±0.10(Predicted)
- color
- White to Orange to Green
- InChIKey
- DFWVLCJRFGIRAK-HRAATJIYSA-N
- CAS DataBase Reference
- 149809-43-8(CAS DataBase Reference)
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(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester Usage And Synthesis
Description
(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester is a pharmaceutical intermediate ingredient for Posaconazole is one of the newest triazole antifungal agents approved by the FDA for the prevention of invasive Aspergillus and Candida infections in immunocompromised patients. Such patients include haematopoietic stem cell transplant patients with graft-versus-host disease and patients with haematological malignancies undergoing chemotherapy.
Chemical Properties
White Crystalline Solid
Uses
Posaconazole intermediate. Antifungal agent.
(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl esterSupplier
Tianjin Liontec Biopharma Co.,Ltd. Gold
- Tel
- 022-87601716 13920326762
- yzhang@liontec.com.cn
Xi'an Manareco New Materials Co., Ltd. Gold
- Tel
- 029-02968669089-8816
- market@xarlm.com
Beijing Zhongshuo Pharmaceutical Technology Development Co., Ltd Gold
- Tel
- 010-53679529 13801208576
- sales.2@chinazhongshuo.com
Tianjin Chempharmatech Co.,Ltd. Gold
- Tel
- 022-66211079 13212288319
- sales@chempharmatech.com
Chengdu Better Pharmaceutical Technology Co.,Ltd. Gold
- Tel
- 18280102635; 18280102635
- sales@betterwanhe.com
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(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester(149809-43-8)Related Product Information
- Folic acid
- Citric acid
- 5-Methyl-1H-benzotriazole
- Ethyl 2-(Chlorosulfonyl)acetate
- 1,2,4-Triazole
- Voriconazole
- Posaconazole
- 2-[(1S,2S)-1-ethyl-2-bezyloxypropyl]-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]- 3H-1,2,4-Triazol-3-one,
- 1H-Benzotriazole
- Ribavirin
- D-threo-Pentitol, 2,5-anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-(hydroxyMethyl)-1-(1H-1,2,4-triazol-1-yl)-
- Ascoric Acid
- Posaconazole Impurity 44
- Posaconazole Impurity 17
- Posaconazole iMpurity 4
- Posaconazole DiastereoisoMer interMediate 2
- PHENYL {4-[4-(4-HYDROXYPHENYL)PIPERAZIN-1-YL]PHENYL}CARBAMATE
- Posaconazole inter-8