Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  Pharmaceutical intermediates >  Bulk Drug Intermediates >  (5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester

(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester

Basic information Safety Supplier Related

(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester Basic information

Product Name:
(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester
Synonyms:
  • Posaconazole Impurity 53
  • ((3S,5R)-5-((1H-1,2,4-triazol-1-yl)Methyl)-5-(2,4-difluorophenyl)-tetrahydrofuran-3-yl)Methyl 4-Methylbenzenesulfonate
  • Posaconazole InterMediates
  • 2,5-Anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[[(4-Methylphenyl)sulfonyl]oxy]Methyl]-1-(1H-1,2,4-triazol-1-yl)-D-threo-pentitol
  • (5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)Methyltetrahydrofuran-3-ylMethyl ester- (POA)
  • (5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4
  • Toluene-4-sulfonica cid 5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylMethyl-tetrahydro-furan-3-ylMethyl ester
  • ((3R,5R)-5-((1H-1,2,4-triazol-1-yl)Methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)Methyl 4-Methylbenzenesulfonate
CAS:
149809-43-8
MF:
C21H21F2N3O4S
MW:
449.47
EINECS:
1308068-626-2
Product Categories:
  • Aromatics
  • Chiral Reagents
  • Intermediates
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
149809-43-8.mol
More
Less

(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester Chemical Properties

Melting point:
100-102°C
Boiling point:
608.1±65.0 °C(Predicted)
Density 
1.40
storage temp. 
-20°C Freezer, Under Inert Atmosphere
solubility 
slightly sol. in Chloroform
form 
powder to crystal
pka
2.75±0.10(Predicted)
color 
White to Orange to Green
InChIKey
DFWVLCJRFGIRAK-HRAATJIYSA-N
CAS DataBase Reference
149809-43-8(CAS DataBase Reference)
More
Less

Safety Information

HS Code 
2934.99.4400
More
Less

(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester Usage And Synthesis

Description

(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester is a pharmaceutical intermediate ingredient for Posaconazole is one of the newest triazole antifungal agents approved by the FDA for the prevention of invasive Aspergillus and Candida infections in immunocompromised patients. Such patients include haematopoietic stem cell transplant patients with graft-versus-host disease and patients with haematological malignancies undergoing chemotherapy.

Chemical Properties

White Crystalline Solid

Uses

Posaconazole intermediate. Antifungal agent.

(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl esterSupplier

Tianjin Liontec Biopharma Co.,Ltd. Gold
Tel
022-87601716 13920326762
Email
yzhang@liontec.com.cn
Xi'an Manareco New Materials Co., Ltd. Gold
Tel
029-02968669089-8816
Email
market@xarlm.com
Beijing Zhongshuo Pharmaceutical Technology Development Co., Ltd Gold
Tel
010-53679529 13801208576
Email
sales.2@chinazhongshuo.com
Tianjin Chempharmatech Co.,Ltd. Gold
Tel
022-66211079 13212288319
Email
sales@chempharmatech.com
Chengdu Better Pharmaceutical Technology Co.,Ltd. Gold
Tel
18280102635; 18280102635
Email
sales@betterwanhe.com