(6R-(6-alpha,7-alpha))-7-((((2-Amino-2-carboxyethyl)thio)acetyl)amino)-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid monosodium salt Chemical Properties

Melting point:

90-91 °C

storage temp. 

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

solubility 

DMSO (Slightly), Methanol (Slightly), Water (Slightly)

form 

Solid

color 

White to Pale Yellow

Water Solubility 

Water: 83.33 mg/mL (153.87 mM)

(6R-(6-alpha,7-alpha))-7-((((2-Amino-2-carboxyethyl)thio)acetyl)amino)-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid monosodium salt Usage And Synthesis

Chemical Properties

White Solid

Uses

Cefminox is a semisynthetic broad spectrum cephamycin antibiotic. Antibacterial.

Definition

ChEBI: Cefminox sodium is an organic sodium salt of cefminox. It contains a cefminox(1-).

Synthesis

Synthesis of (6R,7S)-7-(2-((S)-2-amino-2-carboxyethyl)thio)acetamido)-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0 The general procedure for the sodium salt of ]oct-2-ene-2-carboxylic acid was as follows: 433.1 g of 7β-chloroacetamido-7a-methoxy-3-(1-methyl-1H-tetrazol-5-ylthiomethyl)-3-cephalosporan-4-carboxylic acid was added to 2 L of water, followed by the addition of 30 g of EDTA and 412 g of sodium thiosulfate. The reaction mixture was stirred at 50 °C and the progress of the reaction was monitored by thin layer chromatography (TLC). After completion of the reaction, the mixture was cooled to room temperature and a mixed solution consisting of 1500 mL of ethanol and 500 mL of acetone was added. The resulting precipitate was filtered and dried to give 530 g of cefminox sodium in 97.9% yield. The product was analyzed by high performance liquid chromatography (HPLC) and the purity was 99.5%.

IC 50

PPARγ; IP Receptor; Bacterial

References

[1] Patent: CN105924456, 2016, A. Location in patent: Paragraph 0033; 0035

(6R-(6-alpha,7-alpha))-7-((((2-Amino-2-carboxyethyl)thio)acetyl)amino)-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid monosodium salt(75498-96-3)Related Product Information

• Sodium acetate
• Carbenicillin disodium
• Sodium hydroxide
• Sodium gluconate
• ALTRENOGEST
• Cephalexin
• Sodium carboxymethyl cellulose
• Acetylacetone
• Sodium benzoate
• Glycine
• Sodium chloride
• Acetyl chloride
• Sodium carbonate
• Sodium carboxyl methylstarch
• Sodium bicarbonate
• Cefminox
• p-(2-Methoxyethyl) phenol
• Oxygen