31C
31C Basic information
- Product Name:
- 31C
- Synonyms:
-
- WPE-III-31C
- GAMMA-SECRETASE INHIBITOR XVII
- 31C
- III-31-C
- N-[[[(2R,3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-4-phenylbutyl](phenylmethyl)amino]carbonyl]-L-leucyl-L-valine methyl ester
- L-Valine, N-[[[(2R,3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-4-phenylbutyl](phenylmethyl)amino]carbonyl]-L-leucyl-, methyl ester
- III-31-C >=98% (HPLC), solid
- CAS:
- 398515-96-3
- MF:
- C35H52N4O7
- MW:
- 640.81
- Mol File:
- 398515-96-3.mol
31C Chemical Properties
- Boiling point:
- 832.6±65.0 °C(Predicted)
- Density
- 1.135±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: ≥9mg/mL
- form
- solid
- pka
- 12.04±0.46(Predicted)
31C Usage And Synthesis
Uses
III-31-C is a (hydroxyethyl)urea γ-secretase inhibitor. III-31-C inhibits A? production with an IC50 of 10 nM in the cell-free γ-secretase assay and 200 nM in APP-transfected cells. III-31-C can be used in Alzheimer's disease research[1].
Biological Activity
III-31-C is a (hydroxyethyl)urea γ-secretase inhibitor th at binds to γ-secretase at the substrate docking site. DAPT, also a γ-secretase inhibitor binds to the substrate docking site as well. III-31-C is useful for the affinity isolation and characterization of the protease complex and for testing other ihhibitors th at affect the γ-secretase active site. The γ-secretase complex is composed of presenilin as a catalytic component and three integral membrane proteins, nicastrin, Aph-1 and Pen-2.
References
[1] Kornilova AY, et al. Differential effects of inhibitors on the gamma-secretase complex. Mechanistic implications. J Biol Chem. 2003 May 9;278(19):16470-3. DOI:10.1074/jbc.C300019200