4-Methoxyfuro[2,3-b]quinolin-8-ol
4-Methoxyfuro[2,3-b]quinolin-8-ol Basic information
- Product Name:
- 4-Methoxyfuro[2,3-b]quinolin-8-ol
- Synonyms:
-
- 4-Methoxyfuro[2,3-b]quinolin-8-ol
- Robustine
- 8-Hydroxydictamnine
- NPLC 0314
- Robustine (Haplophyllum)
- 8-hydroxy dictanmnine
- Furo[2,3-b]quinolin-8-ol, 4-methoxy-
- alkaloid,phosphodiesterase,Phosphodiesterase (PDE),Robustine,PDE5A,inhibit,Inhibitor
- CAS:
- 2255-50-7
- MF:
- C12H9NO3
- MW:
- 215.2
- Product Categories:
-
- Alkaloids
- Mol File:
- 2255-50-7.mol
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4-Methoxyfuro[2,3-b]quinolin-8-ol Chemical Properties
- Melting point:
- 148-149℃ (ethanol )
- Boiling point:
- 411.9±40.0 °C(Predicted)
- Density
- 1.378±0.06 g/cm3(Predicted)
- storage temp.
- 4°C, protect from light
- form
- Solid
- pka
- 5.34±0.30(Predicted)
- color
- White to off-white
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4-Methoxyfuro[2,3-b]quinolin-8-ol Usage And Synthesis
Description
Haplophyllum robustum Bge. yields this alkaloid which forms colourless crystals from EtOH. It forms a series of crystalline salts and derivatives including the hydrochloride, m.p. 199-200°C; picrate, m.p. I 79-180°C; acetyl derivative, m.p.174-5°C; methyl derivative, m.p. 140-2°C and the tetrahydrG compound with m.p.201-2°C.
Definition
ChEBI: A quinoline alkaloid that is furo[2,3-b]quinoline substituted by a methoxy and a hydroxy group at positions 4 and 8 respectively.
References
Fakhritdinova, Sidyakin, Yunusov,Khim. Prir.Soedin., 1, 107 (1965)
Faizutdinova, Yunusov, ibid, 3, 260 (1967)
Narasimhan, Paradkar, Alurkar, Tetrahedron, 27,1351 (1971)
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