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4-Methoxyfuro[2,3-b]quinolin-8-ol

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4-Methoxyfuro[2,3-b]quinolin-8-ol Basic information

Product Name:
4-Methoxyfuro[2,3-b]quinolin-8-ol
Synonyms:
  • 4-Methoxyfuro[2,3-b]quinolin-8-ol
  • Robustine
  • 8-Hydroxydictamnine
  • NPLC 0314
  • Robustine (Haplophyllum)
  • 8-hydroxy dictanmnine
  • Furo[2,3-b]quinolin-8-ol, 4-methoxy-
  • alkaloid,phosphodiesterase,Phosphodiesterase (PDE),Robustine,PDE5A,inhibit,Inhibitor
CAS:
2255-50-7
MF:
C12H9NO3
MW:
215.2
Product Categories:
  • Alkaloids
Mol File:
2255-50-7.mol
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4-Methoxyfuro[2,3-b]quinolin-8-ol Chemical Properties

Melting point:
148-149℃ (ethanol )
Boiling point:
411.9±40.0 °C(Predicted)
Density 
1.378±0.06 g/cm3(Predicted)
storage temp. 
4°C, protect from light
form 
Solid
pka
5.34±0.30(Predicted)
color 
White to off-white
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4-Methoxyfuro[2,3-b]quinolin-8-ol Usage And Synthesis

Description

Haplophyllum robustum Bge. yields this alkaloid which forms colourless crystals from EtOH. It forms a series of crystalline salts and derivatives including the hydrochloride, m.p. 199-200°C; picrate, m.p. I 79-180°C; acetyl derivative, m.p.174-5°C; methyl derivative, m.p. 140-2°C and the tetrahydrG compound with m.p.201-2°C.

Definition

ChEBI: A quinoline alkaloid that is furo[2,3-b]quinoline substituted by a methoxy and a hydroxy group at positions 4 and 8 respectively.

References

Fakhritdinova, Sidyakin, Yunusov,Khim. Prir.Soedin., 1, 107 (1965)
Faizutdinova, Yunusov, ibid, 3, 260 (1967)
Narasimhan, Paradkar, Alurkar, Tetrahedron, 27,1351 (1971)

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