1-Bromo-2-(2-methoxyethoxy)ethane Chemical Properties

Boiling point:

156 °C (lit.) 37-40 °C/0.01 mmHg (lit.)

Density 

1.3600 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.455(lit.)

Flash point:

163 °F

storage temp. 

2-8°C

form 

Liquid

color 

Clear colorless to pale yellow

Water Solubility 

Not miscible in water.

Sensitive 

Light Sensitive

BRN 

2069579

InChI

InChI=1S/C5H11BrO2/c1-7-4-5-8-3-2-6/h2-5H2,1H3

InChIKey

HUXJXNSHCKHFIL-UHFFFAOYSA-N

SMILES

C(OCCBr)COC

CAS DataBase Reference

54149-17-6(CAS DataBase Reference)

NIST Chemistry Reference

1-Bromo-2-(2-methoxyethoxy)ethane(54149-17-6)

Safety Information

Risk Statements 

36/37/38

Safety Statements 

24/25

WGK Germany 

3

HS Code 

29091990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

1-Bromo-2-(2-methoxyethoxy)ethane Usage And Synthesis

Chemical Properties

clear colorless to pale yellow liquid

Uses

1-Bromo-2-(2-methoxyethoxy)ethane is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.

Synthesis

 General Procedure for Preparation of 1-Bromo-2-(2-methoxyethoxy)ethane: Into a 25-mL round bottomed flask equipped with magnetic stir bar, addition funnel and positive flow of nitrogen were placed 15.60 mmol of a ethyleneglycol monomethyl ether. The solution was stirred for 15 min in an ice bath before the dropwise addition of phosphorous tribromide (7.81 mmol) over a 10 min period. The solution was allowed to gradually warm and stir at room temperature (rt) for 14 hrs. The solution was then heated in a 90 °C oil bath for 1 hr, at which time the solution turned yellow. The solution was allowed to cool to rt, poured onto 30 g of ice/water mixture, and made slightly basic with addition of a 10% solution of NaHCO3 (~6 mL). Subsequent extraction with diethyl ether (Et2O) (3 x 30 mL), followed by drying over MgSO4 and concentration under reduced pressure afforded a colorless oil in sufficient purity for use in subsequent reactions.

1-Bromo-2-(2-methoxyethoxy)ethane(54149-17-6)Related Product Information

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