ChemicalBook > Product Catalog > Natural Products > Xanthones > J167.440D1,5-Dihydroxy-6',6'-dimethylpyrano[2',3':3,2]xanthone
J167.440D1,5-Dihydroxy-6',6'-dimethylpyrano[2',3':3,2]xanthone
J167.440D1,5-Dihydroxy-6',6'-dimethylpyrano[2',3':3,2]xanthone Basic information
- Product Name:
- J167.440D1,5-Dihydroxy-6',6'-dimethylpyrano[2',3':3,2]xanthone
- Synonyms:
-
- 5,10-Dihydroxy-2,2-dimethyl-2H,6H-pyrano[3,2-b]xanthen-6-one
- 6-Deoxyjacareubin
- 9-Deshydroxyjacareubin
- J167.440D1,5-Dihydroxy-6',6'-dimethylpyrano[2',3':3,2]xanthone
- 6-Dehydroxyjacareubin
- 6-Desoxyjacareubin
- 2H,6H-Pyrano[3,2-b]xanthen-6-one, 5,10-dihydroxy-2,2-dimethyl-
- 5,10-dihydroxy-2,2-dimethylpyrano[3,2-b]xanthen-6-one
- CAS:
- 16265-56-8
- MF:
- C18H14O5
- MW:
- 310.3
- Mol File:
- 16265-56-8.mol
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J167.440D1,5-Dihydroxy-6',6'-dimethylpyrano[2',3':3,2]xanthone Chemical Properties
- Melting point:
- 214-215℃
- Boiling point:
- 523.4±50.0 °C(Predicted)
- Density
- 1.410±0.06 g/cm3(Predicted)
- pka
- 6.59±0.40(Predicted)
- form
- Solid
- color
- Light yellow to yellow
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J167.440D1,5-Dihydroxy-6',6'-dimethylpyrano[2',3':3,2]xanthone Usage And Synthesis
Uses
6-Deoxyjacareubin is a natural xanthone, that can be isolated from the leaves of Vismia latifolia. 6-Deoxyjacareubin protects against non-apoptotic cell death by inhibiting ROS production. 6-Deoxyjacareubin ameliorates neurodegeneration in a mouse model of familial amyotrophic lateral sclerosis (ALS)[1].
Definition
ChEBI: 6-Deoxyjacareubin is a member of pyranoxanthones.
in vivo
6-Deoxyjacareubin (5 mg/kg, i.p., every seven days for 1 month) attenuates motor neuron loss in familial ALS model mice[1].
| Animal Model: | Male SOD1G93A mice (eight weeks)[1] |
| Dosage: | 5 mg/kg |
| Administration: | Intraperitoneally (i.p.), every seven days for 1 month |
| Result: | Prolonged the survival time of SOD1G93A mice and improved their locomotor dysfunction. Suppressed glial activation and showed protective effect on motor neuron loss. |
References
[1] Hoshino T, et al. 6-Deoxyjacareubin, a natural compound preventing hypoxia-induced cell death, ameliorates neurodegeneration in a mouse model of familial amyotrophic lateral sclerosis. Neurosci Res. 2021 Feb;163:43-51. DOI:10.1016/j.neures.2020.02.011
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