SENEGENIN Chemical Properties

Melting point:

290-292℃

alpha 

D +19° (c = 0.70 in ethanol)

Boiling point:

674.1±55.0 °C(Predicted)

Density 

1.28

storage temp. 

2-8°C

solubility 

DMSO: soluble10mg/mL, clear

pka

4.27±0.70(Predicted)

form 

powder

color 

white to beige

Safety Information

WGK Germany 

3

RTECS 

RC8815000

Toxicity

LD50 intraperitoneal in mouse: 3mg/kg

SENEGENIN Usage And Synthesis

Description

Tenuigenin is a triterpenoid sapogenin that has been found in P. tenuifolia and has diverse biological activities, including antioxidant, anti-inflammatory, and neuroprotective properties. It inhibits IL-1β and reactive oxygen species (ROS) production from LPS-induced mouse BV2 microglia at a concentration of 4 μM. Tenuigenin (25 mg/kg per day) decreases NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome activation and prevents dopaminergic neuronal degeneration in the mouse substantia nigra pars compacta in an MPTP-induced model of Parkinson''s disease. Tenuigenin (2 mg/kg) also reduces increases in lung edema and the levels of IL-1β and TNF-α in bronchoalveolar lavage fluid (BALF) in a mouse model of intranasal S. aureus-induced pneumonia.

Uses

Tenuifgenin is a Chinese herbal extract with anti-oxidative and anti-inflammatory effects involving toxin induced cell models of Parkinson’s disease.

Definition

ChEBI: Senegenin is a 12alpha-hydroxy steroid.

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