1,4-Benzodioxane-2-carboxylic acid Chemical Properties

Melting point:

126-130 °C(lit.)

CAS DataBase Reference

34385-93-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

WGK Germany 

3

HazardClass 

IRRITANT

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

1,4-Benzodioxane-2-carboxylic acid Usage And Synthesis

Uses

1,4-Benzodioxane-2-carboxylic Acid can be used in decarboxylative amination or fluorination reactions.

Purification Methods

1,4-Benzodioxane-2-carboxylic Acid has two isomeric forms, (S) and (R), which can be separated by crystalline salts. The diastereomeric N-1-phenylethylamides of (S)- and (R)-1,4-benzodioxane-2-carboxylic Acid differ significantly in melting and solubility, and can therefore be efficiently discriminated by precipitation of the less soluble diastereoisomers (>98%de), whereas chromatographic purification of the unprecipitated portion results in the soluble diastereoisomers (>99%de). Overall, recoveries were 95% for the former and 80% for the latter. Hydrolysis of the two catabolic amides gave the two acid enantiomers and the catabolic amine in quantitative yields with no change in stereoisomer purity.

1,4-Benzodioxane-2-carboxylic acid(34385-93-8)Related Product Information

• 1,4-Benzodioxane-2-carboxylic acid
• (S)-1,4-BENZODIOXANE-2-CARBOXYLIC ACID
• (R)-1,4-BENZODIOXANE-2-CARBOXYLIC ACID
• RAC 1,4-BENZODIOXANE-2-CARBOXYLIC ACID
• 1,4-BENZODIOXANE-6-CARBOXYLIC ACID
• 1,4-BENZODIOXANE-5-CARBOXYLIC ACID
• 1,4-Benzodioxan
• METHYL 1,4-BENZODIOXAN-2-CARBOXYLATE
• 6-NITRO-2,3-DIHYDRO-BENZO[1,4]DIOXINE-2-CARBOXYLIC ACID
• ETHYL 1,4-BENZODIOXAN-2-CARBOXYLATE
• 6-TERT-BUTYL-2,3-DIHYDRO-BENZO[1,4]DIOXINE-2-CARBOXYLIC ACID
• 3-METHYL-2,3-DIHYDRO-1,4-BENZODIOXINE-2-CARBOXYLIC ACID
• 6-Chloro-4,4-diphenyl-1,3-benzodioxane-2-carboxylic acid methyl ester
• AURORA 4843
• 1,4-Benzodioxan-2-carboxylic acid, 3-phenyl-, 2-(2-(diethylamino)ethox y)ethyl ester, citrate, (E)-
• AURORA 12103
• trans-2-(Diethylamino)ethyl 2,3-dihydro-3-phenyl-1,4-benzodioxin-2-car boxylate citrate
• METHYL 3-METHYL-2,3-DIHYDRO-1,4-BENZODIOXINE-2-CARBOXYLATE