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Ferrous gluconate

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Ferrous gluconate Basic information

Product Name:
Ferrous gluconate
Synonyms:
  • irox(gador)
  • nionate
  • ray-gluciron
  • iron digluconate
  • Ferrous Gluconate NF, Powder
  • Ferrous Gluconate USP/FCC, Granular
  • Ferrous Gluconate(CIQ)
  • Ferrous Gluconate, Granular
CAS:
299-29-6
MF:
C12H20FeO14
MW:
444.12
EINECS:
206-076-3
Product Categories:
  • Organometallics
  • Food additive
Mol File:
299-29-6.mol
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Ferrous gluconate Chemical Properties

Density 
0.79[at 20℃]
vapor pressure 
2.399hPa at 10℃
solubility 
Freely but slowly soluble in water giving a greenish-brown solution, more readily soluble in hot water, practically insoluble in ethanol (96 per cent).
pka
6.28[at 20 ℃]
Odor
at 100.00?%. caramellic
Water Solubility 
118g/L at 25℃
Stability:
May be light-sensitive - store in the dark.
LogP
-2.6 at 25℃
CAS DataBase Reference
299-29-6(CAS DataBase Reference)
EPA Substance Registry System
Iron, bis(D-gluconato-.kappa.O1,.kappa.O2)- (299-29-6)
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Safety Information

Safety Statements 
22-24/25
WGK Germany 
2
RTECS 
LZ5150000
Hazardous Substances Data
299-29-6(Hazardous Substances Data)
Toxicity
child,TDLo,oral,162mg/kg (162mg/kg),GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"GASTROINTESTINAL: NAUSEA OR VOMITING,JAMA, Journal of the American Medical Association. Vol. 218, Pg. 1179, 1971.

MSDS

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Ferrous gluconate Usage And Synthesis

Chemical Properties

Ferrous Gluconate is a yellow-gray or light green-yellow fine powder or granules with a slightly caramel-like smell. Soluble in water (10g/100mg warm water), almost insoluble in ethanol. The 5% aqueous solution is acidic to litmus, and the aqueous solution can be stabilized by adding glucose.

Uses

Ferrous Gluconate is a nutrient and dietary supplement that is a source of iron and a coloring adjunct. it is a yellowish gray to pale greenish yellow powder or granules with a burnt sugar odor. it has a solubility of 1 g in approximately 10 ml of water with slight heating. it is used by the pharmaceutical industry as an iron supplement in vitamin pills. it is used by olive growers to darken the olives to a uniform black color. it can function as an iron fortifier in corn and soy products, breakfast cereals, beverages, and dietary foods.

Preparation

Ferrous gluconate is prepared from barium gluconate and iron sulfate.

Biological Functions

Ferrous Gluconate is a form of mineral iron for oral administration, Ferrous Gluconate is absorbed in the stomach and small intestine and combines with apoferritin to form ferritin, which is stored in the liver, spleen, red bone marrow, and intestinal mucosa. Important in transport of oxygen by hemoglobin to the tissues, iron is also found in myoglobin, transferrin, and ferritin, and is as a component of many enzymes such as catalase, peroxidase, and cytochromes. (NCI04)

General Description

Ferrous Gluconate is an iron mineral salt used in iron and multivitamin supplements. It is used to treat or prevent iron deficiency anemia (a lack of red blood cells caused by having too little iron in the body).

Flammability and Explosibility

Non flammable

Safety Profile

Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. Human systemic effects by ingestion: hypermothty, diarrhea, nausea, and vomiting. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits acrid smoke and irritating fumes.

Drug interactions

Potentially hazardous interactions with other drugs
Antibacterials: reduced absorption of 4-quinolones and tetracyclines.
Dimercaprol: avoid concomitant use.
Mycophenolate: may significantly reduce absorption of mycophenolate.

Metabolism

Following absorption, the majority of iron is bound to transferrin and transported to the bone marrow where it is incorporated into haemoglobin. The remainder is stored within ferritin or haemosiderin or is incorporated into myoglobin with smaller amounts occurring in haemcontaining enzymes or in plasma bound to transferrin. Only very small amounts are excreted as the body reabsorbs the iron after the haemoglobin has broken down.

Ferrous gluconate Preparation Products And Raw materials

Raw materials

Ferrous gluconateSupplier

Jiangxi New Ganjiang Pharmaceutical Co., Ltd. Gold
Tel
0796-8280516
Email
jxxinganjiang@163.com
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Email
3bsc@sina.com
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Email
isenchem@163.com
XiaoGan ShenYuan ChemPharm co,ltd
Tel
0712-0712-2580635 15527768850
Email
1791901229@qq.com
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Email
3007715519@qq.com