ACRIFLAVINE Chemical Properties

Melting point:

179-181 °C

Boiling point:

612.69°C (rough estimate)

Density 

1.0933 (rough estimate)

refractive index 

1.6000 (estimate)

storage temp. 

Store at -20°C

solubility 

H2O: soluble0.33g/mL (lit.)(lit.)

form 

Powder

color 

Deep orange to brownish-red

Water Solubility 

H2O: 0.33g/mL (lit.)(lit.)

Merck 

14,123

CAS DataBase Reference

8048-52-0(CAS DataBase Reference)

EPA Substance Registry System

Xanthacridinum (8048-52-0)

Safety Information

Hazard Codes 

Xn,N

Risk Statements 

22-37/38-41-50/53-20/21/22-50-36/37/38

Safety Statements 

26-39-60-61-36-37/39-29-36/37/39

RIDADR 

UN 3077 9/PG 3

WGK Germany 

3

RTECS 

AR9660000

HS Code 

38249064

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich

ACRIFLAVINE Usage And Synthesis

Chemical Properties

Acriflavine hydrochloride is deep orange to brownish-red powder

Uses

Acriflavine is used in applications for dual fluorescence analysis of cellular DNA and protein simultaneously.

Uses

Fluorescent label for high molecular weight RNA

Biological Activity

Acriflavine also interacts with HIF-1α (hypoxia-inducible factor 1 α) and HIF-2α, and thereby suppresses dimer formation of HIF-1 and transcriptional function. It also has negative effect on tumor growth and vascularization. Acriflavine also exhibits trypanocidal, antibacterial and antiviral activities.

Safety Profile

Poison by subcutaneous route. Questionable carcinogen with experimental tumorigenic data. Human mutation data reported. A topical antiseptic used in the treatment of gonorrhea. When heated to decomposition it emits very toxic fumes of NOx and Cl-. See also 3,6-DIAMINO-10 METHYLACRIDINIUM CHLORIDE.

Purification Methods

Treat acriflavin twice with freshly precipitated AgOH to remove proflavine, then recrystallise it from absolute methanol [Wen & Hsu J Phys Chem 66 1353 1962]. [Beilstein 22 III/IV 218.]

ACRIFLAVINE(8048-52-0)Related Product Information

• ACRIDINE ORANGE
• Neutral Red
• meso-Tetra(4-carboxyphenyl)porphine
• SCINTIVERSE BD COCKTAIL
• ACRIFLAVINE
• PROFLAVINE HEMISULFATE
• ACRIDINE HYDROCHLORIDE
• Acriflavine hydrochloride
• ACRIFLAVINE HYDROCHLORIDE
• PROFLAVINE
• CI 46025
• Chloromethane
• 2 8-DIAMINO-10-METHYLACRIDINIUM CHLORIDE HYDROCHLORIDE,3,6-DIAMINO-10-METHYLACRIDINIUM CHLORIDE
• 3,6-diamino-10-methylacridinium
• Neutral acriflavine
• Acid acriflavine
• Acrifiavine hydrochloride
• 10-METHYLACRIDINIUMCHLORIDE