(23R,24S)-24,25-Epoxy-23-hydroxy-5α-tirucall-7-en-3-one Chemical Properties

Melting point:

149-151 °C

Boiling point:

538.5±45.0 °C(Predicted)

Density 

1.07±0.1 g/cm3(Predicted)

solubility 

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

form 

Cryst.

pka

14.37±0.20(Predicted)

color 

White to off-white

(23R,24S)-24,25-Epoxy-23-hydroxy-5α-tirucall-7-en-3-one Usage And Synthesis

Uses

Niloticin, tetracyclic triterpenoid compound, is a osteoclastogenesis inhibitor. Niloticin shows anti-viral, antioxidative, and mosquitocidal activities. Niloticin inhibits osteoclastogenesis by blocking RANKL-RANK interaction and suppressing the AKT, MAPK, and NF-κB signaling pathways[1].

References

[1] Xu H, et al. Niloticin inhibits osteoclastogenesis by blocking RANKL-RANK interaction and suppressing the AKT, MAPK, and NF-κB signaling pathways. Biomed Pharmacother. 2022 May;149:112902. DOI:10.1016/j.biopha.2022.112902

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