Cefmetazole sodium
Cefmetazole sodium Basic information
- Product Name:
- Cefmetazole sodium
- Synonyms:
-
- Cefmetazone
- 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[[(cyanomethyl)thio]acetyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, monosodium salt, (6R,7S)-
- 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[[(cyanomethyl)thio]acetyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, monosodium salt, (6R-cis)-
- Cefmetazole-Na
- CS-1170 sodium salt
- Metafar
- Sodium cefmetazole
- (6R,7S)-7-[[2-[(Cyanomethyl)thio]acetyl]amino]-7-methoxy-3-[[(1-methyl -1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene -2-carboxylic Acid Sodium Salt
- CAS:
- 56796-39-5
- MF:
- C15H18N7NaO5S3
- MW:
- 495.52
- EINECS:
- 627-393-7
- Product Categories:
-
- Sulfur & Selenium Compounds
- A - KAntibiotics
- Antibacterial
- Antibiotics A to
- Antibiotics A-FAntibiotics
- Chemical Structure Class
- Chiral Reagents
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Interferes with Cell Wall SynthesisAntibiotics
- Mechanism of Action
- Penicillins and Cephalosporins (beta-Lactams)
- Spectrum of Activity
- Mol File:
- 56796-39-5.mol
Cefmetazole sodium Chemical Properties
- Melting point:
- >130°C (dec.)
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- H2O: soluble50mg/mL
- form
- powder
- color
- White to Off-White
- Water Solubility
- Soluble in water
- Sensitive
- Hygroscopic
- Merck
- 14,1926
- Stability:
- Hygroscopic
- InChIKey
- BITQGIOJQWZUPL-PBCQUBLHSA-M
- CAS DataBase Reference
- 56796-39-5(CAS DataBase Reference)
Safety Information
- Hazard Codes
- Xn,Xi
- Risk Statements
- 36/37/38-42/43
- Safety Statements
- 26-36
- WGK Germany
- 2
- RTECS
- XI0372200
- HS Code
- 2941.90.3000
- Toxicity
- LD50 i.v. in rats: >5000 mg/kg (Masuda)
Cefmetazole sodium Usage And Synthesis
Chemical Properties
White Solid
Uses
Semi-synthetic antibiotic derived from Cephamycin. Antibacterial
Uses
Cefmetazole sodium is used clinically in combination with Tanreqing for the treatment of Pulmonary infections like Senile Emphysema and other acute bacterial infections.
Definition
ChEBI: An organic sodium salt that is the sodium salt of cefmetazole.
brand name
Zefazone (Pharmacia & Upjohn）.
Clinical Use
Cefmetazole (Zefazone) is a semisynthetic, third-generation,parenteral cephalosporin of the cephamycin group. Likeother cephamycins, the presence of the 7α-methoxyl groupconfers resistance to many β-lactamases. Cefmetazoleexhibits significantly higher potency against members ofthe Enterobacteriaceae family but lower activity againstBacteroides spp. than cefoxitin. It is highly active againstN. gonorrhoeae, including -lactamase–producing strains. Incommon with other cephamycins, cefmetazole is ineffectiveagainst indole-positive Proteus, Enterobacter, Providencia,Serratia, and Pseudomonas spp. Cefmetazole has the MTTmoiety associated with increased bleeding in certain highriskpatients. It has a plasma half-life of 1.1 hours.
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