Molsidomine Chemical Properties

Melting point:

140-141°C

Boiling point:

385.05°C (rough estimate)

Density 

1.3186 (rough estimate)

refractive index 

1.6300 (estimate)

storage temp. 

Inert atmosphere,2-8°C

solubility 

Sparingly soluble in water, soluble in anhydrous ethanol and in methylene chloride.

pka

pK (100°) 3.0 ± 0.1

form 

Solid

color 

White to Off-White

λmax

317nm(MeOH)(lit.)

Merck 

14,6234

CAS DataBase Reference

25717-80-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

Safety Statements 

36

WGK Germany 

3

RTECS 

WU7677400

HS Code 

29349990

Toxicity

LD50 in male, female mice, male, female rats (mg/kg): 780, 750, 1380, 1350 s.c.; 860, 800, 830, 760 i.v.; 700, 760, 1250, 1250 i.p.; 830, 840, 1050, 1200 orally (Nakaguchi)

MSDS

• Language:English Provider:N-Carboxy-3-morpholinosynonimine ethyl ester

Molsidomine Usage And Synthesis

Chemical Properties

White to Off-White Solid

Originator

Corvasal,Hoechst

Uses

Molsidomine is an antianginal agent. Molsidomine is an effective therapeutic agents in the treatment of angina pectoris. Molsidomine is a sydnonimine derivative that acts as a heterocyclic direct nitric oxide donor.

Definition

ChEBI: 1-ethoxy-N-[3-(4-morpholinyl)-5-oxadiazol-3-iumyl]methanimidate is a member of morpholines.

Manufacturing Process

1.6 parts by volume of ethyl chloroformate is stirred dropwise into a suspension of 1.0 part by weight of 3-morpholinosydnonimine hydrochloride in 5 parts by volume of pyridine, and the mixture is agitated for a while to allow reaction to take place. Pyridine is removed from the reaction mixture by evaporation, and the residue is dissolved in a small amount of water and extracted with chloroform several times. The extract is dehydrated by adding anhydrous magnesium sulfate and subjected to filtration. Chloroform is removed from the filtrate by distillation, crude crystals being obtained. Recrystallization of the crude crystals from toluene gives 0.6 part by weight of 3-morpholino-N-carboethoxysydnonimine having a melting point of 140°- 141°C. Yield 51%.

brand name

Corvaton (Hoechst-Roussel).

Therapeutic Function

Coronary vasodilator

Molsidomine(25717-80-0)Related Product Information

• Ethanol
• CHLOROETHANE
• 1-(2,6-Dimethylphenoxy)-2-propanamine
• Ethylparaben
• Tris(trimethylsilyl)phosphate
• Ethyl cellulose
• Ethylbenzene
• Ethyl acrylate
• Ethyl formate
• Ethyl acetate
• Diethyl ether
• 3-MORPHOLINOSYDNONIMINE
• 4-AMINO-2-CHLORO-6,7-DIMETHOXYQUINAZOLINE/ MOLSIDOMINE
• Molsidomine impurity B
• Molsidomine impurity D
• Molsidomine
• MOLSIDOMINE IMP. B (PHARMEUROPA): 4-NITROSOMORPHOLINE
• MOLSIDOMINE IMP. A (PHARMEUROPA) AS HYDROCHLORIDE:3-(MORPHOLIN-4-YL)SYDNONIMINE HYDROCHLORIDE (LINSIDOMINE HYDROCHLORIDE)