4-(2-Bromoacetyl)benzonitrile Chemical Properties

Melting point:

92-96 °C(lit.)

Boiling point:

342.4±22.0 °C(Predicted)

Density 

1.56±0.1 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

soluble in Methanol

form 

Crystalline Powder

color 

Off-white to light yellow

BRN 

2087648

InChIKey

LJANCPRIUMHGJE-UHFFFAOYSA-N

CAS DataBase Reference

20099-89-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

C

Risk Statements 

20/21/22-34

Safety Statements 

26-27-36/37/39-45

RIDADR 

UN 2928 6.1/PG 2

WGK Germany 

3

Hazard Note 

Corrosive

HazardClass 

6.1

PackingGroup 

II

HS Code 

29269090

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

4-(2-Bromoacetyl)benzonitrile Usage And Synthesis

Odor

Irritating

Chemical Properties

off-white to light yellow crystalline powder

Uses

2-Bromo-4′-cyanoacetophenone may be used to synthesize:

• 3-acylindolizines
• (2R,3R)-3-[4-(4-cyanophenyl)thiazol-2-yl]-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol
• 1-[2-(4-cyanophenyl)-2-oxoethyl]-1,10-phenanthrolinium bromide

Uses

4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors.

General Description

2-Bromo-4′-cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.

4-(2-Bromoacetyl)benzonitrile(20099-89-2)Related Product Information

• 2-Bromoacetophenone
• Isavuconazole Impurity 34
• Isavuconazole Impurity 31
• Isavuconazole Impurity 21
• Eltrombopag Impurity 2
• Isavuconazole Impurity 8
• Isavuconazole Impurity 3
• Isavuconazole Impurity 15
• Isavuconazole Impurity 9
• Isavuconazole Impurity 13
• Isavuconazole Impurity 14
• Isavuconazole Impurity 19
• Isavuconazole Impurity 24
• Isavuconazole Impurity 16
• Isavuconazole Impurity 4
• Crotonaldehyde
• Isavuconazole Impurity 22
• Isavuconazole Impurity 28