2-Chloro-6-(trifluoromethyl)pyridine Chemical Properties

Melting point:

33 °C

Boiling point:

60-62°C 8mm

Density 

1.416±0.06 g/cm3(Predicted)

Flash point:

78°C

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

Water Solubility 

Insoluble in water

form 

powder to lump

pka

-4.30±0.10(Predicted)

color 

White to Almost white

FreezingPoint 

32.0 to 34.0 ℃

BRN 

4308910

InChI

InChI=1S/C6H3ClF3N/c7-5-3-1-2-4(11-5)6(8,9)10/h1-3H

InChIKey

ADVQMCQMDHBTHJ-UHFFFAOYSA-N

SMILES

C1(Cl)=NC(C(F)(F)F)=CC=C1

CAS DataBase Reference

39890-95-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

T;Xn,Xi,Xn,T

Risk Statements 

25-20/21/22-36/37/38-36

Safety Statements 

26-36/37/39-45-36/37-9-36

RIDADR 

2811

WGK Germany 

3

Hazard Note 

Irritant

HazardClass 

6.1

PackingGroup 

III

HS Code 

29333990

MSDS

• Language:English Provider:ALFA

2-Chloro-6-(trifluoromethyl)pyridine Usage And Synthesis

Chemical Properties

Colorless to off-white liquid (or White to off-white crystal)

Uses

2-Chloro-6-(trifluoromethyl)pyridine can be used in the synthesis of medicine, pesticide or biocidal product.

Chemical Reactivity

2-Chloro-6-(trifluoromethyl)pyridine is stable under recommended storage conditions, it reacts with strong oxidizing agents, strong acids, strong bases.

Synthesis

General procedure for the synthesis of 2-chloro-6-trichloromethylpyridine from 2-chloro-6-trichloromethylpyridine: 2-chloro-6-trichloromethylpyridine (700 g, 3.03 mol, feed rate 1.24 g/min) and anhydrous hydrogen fluoride (936 g, 46.8 mol, feed rate 1.66 g/min) were added successively to a tubular reactor fitted with a preactivated chromium oxide-alumina catalyst (210 g) in a tubular reactor at a reaction temperature of 330 °C. The reaction products were cooled with ice water and collected. The reaction products were collected after cooling with ice water and extracted with dichloromethane. The extract was washed with 10% potassium hydroxide solution, and the organic layer was separated and concentrated to give 490.0 g of crude 2-chloro-6-trifluoromethylpyridine, which was analyzed by GC for 95.03% purity and 89% reaction yield. The crude product was purified by fractionation to obtain 2-chloro-6-trifluoromethylpyridine with 98.0% purity and 80.0% yield.

References

[1] Patent: WO2016/178248, 2016, A1. Location in patent: Page/Page column 5

2-Chloro-6-(trifluoromethyl)pyridine(39890-95-4)Related Product Information

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