(+)-Bisabolangelone Chemical Properties

Melting point:

157-158 °C

Boiling point:

396.0±42.0 °C(Predicted)

Density 

1.154±0.06 g/cm3(Predicted)

storage temp. 

4°C, protect from light

solubility 

Soluble in DMSO

form 

Solid

pka

14.54±0.40(Predicted)

color 

Off-white to yellow

InChI

InChI=1S/C15H20O3/c1-9(2)5-6-13-15(4,17)14-11(16)7-10(3)8-12(14)18-13/h5-7,12,14,17H,8H2,1-4H3/b13-6-/t12-,14+,15-/m0/s1

InChIKey

GNWNPLBSEQDDQV-VRBKASCLSA-N

SMILES

O1[C@@]2([H])CC(C)=CC(=O)[C@@]2([H])[C@](O)(C)/C/1=C/C=C(/C)\C

(+)-Bisabolangelone Usage And Synthesis

Uses

Bisabolangelone, a sesquiterpene derivative, is isolated from the roots of Osterici Radix. Bisabolangelone possesses anti-inflammatory properties, which inhibits LPS-stimulated inflammation through the blocking of NF-kappaB and MAPK pathways in macrophages. Bisabolangelone has anti-ulcer activities[1][2].

References

[1] Jung HW, et al. Bisabolangelone isolated from Ostericum koreanum inhibits the production of inflammatory mediators by down-regulation of NF-kappaB and ERK MAP kinase activity in LPS-stimulated RAW264.7 cells. Int Immunopharmacol. 2010 Feb;10(2):155-62. DOI:10.1016/j.intimp.2009.10.010
[2] Wang J, et al. The anti-ulcer activities of bisabolangelone from Angelica polymorpha. J Ethnopharmacol. 2009 Jun 22;123(2):343-6. DOI:10.1016/j.jep.2009.02.048

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