6-BROMO-4-METHYLQUINOLIN-2(1H)-ONE Chemical Properties

Melting point:

290-292 °C

Boiling point:

392.6±42.0 °C(Predicted)

Density 

1.523±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

10.79±0.70(Predicted)

Appearance

White to light brown Solid

6-BROMO-4-METHYLQUINOLIN-2(1H)-ONE Usage And Synthesis

Synthesis

(b) N-(4-bromophenyl)-3-oxobutanamide (0.73 g, 2.85 mmol) was dissolved in concentrated hydrochloric acid. The reaction was heated to 120 °C in an oil bath and sodium sulfate (7 mL) was added and kept at this temperature for 1 hour. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently poured into a beaker containing ice. The precipitate precipitated was collected by filtration to afford 6-bromo-4-methyl-2(1H)-quinolinone as a tan solid (0.4 g, 60% yield).

References

[1] Patent: WO2010/132615, 2010, A1. Location in patent: Page/Page column 138
[2] Synthesis, 2011, # 6, p. 934 - 942
[3] Patent: US2005/234101, 2005, A1. Location in patent: Page/Page column 14
[4] Patent: WO2005/103002, 2005, A2. Location in patent: Page/Page column 44
[5] Patent: US2005/267115, 2005, A1. Location in patent: Page/Page column 21

6-BROMO-4-METHYLQUINOLIN-2(1H)-ONE(89446-19-5)Related Product Information

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