2-[(6-CHLORO-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)METHYL]BENZONITRILE Chemical Properties

Density 

1.48

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

Dichloromethane, Ethyl Acetate, Methanol

form 

Solid

pka

8.11±0.40(Predicted)

color 

White

2-[(6-CHLORO-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)METHYL]BENZONITRILE Usage And Synthesis

Chemical Properties

White Solid

Uses

Alogliptin (A575425) intermediate.

Uses

2-((6-Chloro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile is used as a reactant/ intermediate in discovery of Alogliptin (A575425), which is an antidiabetic agent.

2-[(6-CHLORO-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)METHYL]BENZONITRILE(865758-95-8)Related Product Information

• Alogliptin Impurity B
• 2-[(6-Chloro-3,4-dihydro-3-Methyl-2,4-dioxo-1(2h)-pyriMidinyl)Methyl]benzonitrile
• 2-(AMinoMethyl)benzonitrile hydrochloride
• Alogliptin benzoate impurity K
• Benzonitrile, 2-[(tetrahydro-3-Methyl-2,4,6-trioxo-1(2H)-pyriMidinyl)Methyl]-
• Alogliptin Related Compound 26
• α,α-Dibromo-o-tolunitrile
• 2-[(6-CHLORO-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)METHYL]BENZONITRILE
• (R)-2-((3-methyl-2,4-dioxo-6-(piperidin-3-ylamino)-3,4-Dihydro- pyrimidin-1(2H)-yl)methyl)benzonitrile hydrogen chloride
• Alogliptin Related Compound 18
• Alogliptin Impurity 34
• Alogliptin Related Compound 32
• Alogliptin Impurity 35
• Alogliptin Related Compound 21
• (R)-2-((6-(3-((3-(2-cyanobenzyl)-1-Methyl-2,6-dioxo-1,2,3,6-tetrahydropyriMidin-4-yl)aMino)piperidin-1-yl)-3-Methyl-2,4-dioxo-3,4-dihydropyriMidin-1(2H)-yl)Methyl)benzonitrile
• Alogliptin Impurity 16
• Alogliptin Impurity 10
• Alogliptin Related Compound 31