3-(BENZYLOXY)AZETIDINE BENZENESULFONATE Chemical Properties

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

Appearance

White to off-white Solid

InChI

InChI=1S/C10H13NO.ClH/c1-2-4-9(5-3-1)8-12-10-6-11-7-10;/h1-5,10-11H,6-8H2;1H

InChIKey

BQTSSUSLZRYTQB-UHFFFAOYSA-N

SMILES

O(C1CNC1)CC1C=CC=CC=1.Cl

Safety Information

HS Code 

2933998090

3-(BENZYLOXY)AZETIDINE BENZENESULFONATE Usage And Synthesis

Synthesis

General procedure for the synthesis of 3-(benzyloxy)azetidine-1-carboxylic acid tert-butyl ester from 3-(benzyloxy)azetidine-1-carboxylic acid: tert-butyl ester of 3-(benzyloxy)azetidine-1-carboxylic acid (1.0 g) was placed in a round-bottomed flask, methanol-HCl solution (15 ml, 20%) was added, and the reaction was stirred for 1 h at room temperature. The reaction progress was monitored by thin layer chromatography (TLC). After completion of the reaction, the solvent was evaporated under reduced pressure to give the crude product as a white solid. The crude product was washed several times with ethyl acetate and dried thoroughly to afford the target compound 3-(benzyloxy)azetidine hydrochloride as a white solid in 92% yield, which can be used for subsequent reactions without further purification.

References

[1] Patent: WO2012/83246, 2012, A1. Location in patent: Page/Page column 46
[2] Patent: US9388164, 2016, B2. Location in patent: Page/Page column 74; 75
[3] Organic Letters, 2017, vol. 19, # 9, p. 2270 - 2273
[4] Patent: WO2017/202704, 2017, A1. Location in patent: Page/Page column 44; 45

3-(BENZYLOXY)AZETIDINE BENZENESULFONATE(897019-59-9)Related Product Information

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