TYRPHOSTIN A9 Chemical Properties

Melting point:

141-143℃ (ethanol )

Boiling point:

424.99°C (rough estimate)

Density 

1.0741 (rough estimate)

refractive index 

1.5700 (estimate)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

ethanol: 20 mg/mL

form 

solid

pka

7.55±0.40(Predicted)

color 

yellow

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

CAS DataBase Reference

10537-47-0(CAS DataBase Reference)

EPA Substance Registry System

Malonoben (10537-47-0)

Safety Information

Hazard Codes 

T

Risk Statements 

23/24/25

Safety Statements 

36/37/39-45

RIDADR 

UN 2811 6.1/PG 3

WGK Germany 

3

RTECS 

OO3737000

HS Code 

2926.90.5050

HazardClass 

6.1

MSDS

• Language:English Provider:SigmaAldrich

TYRPHOSTIN A9 Usage And Synthesis

Description

Tyrphostin 9 (10537-47-0) inhibits PDGF receptor tyrosine kinase (IC50?= 1.2 μM)1and is a potent (10 nM) inhibitor of oxidative phosphorylation2. Inhibits cell growth by disrupting mitochondria.3 Tyrphostin 9 perturbs the golgi complex and blocks proliferation of vascular smooth muscle cells.4

Uses

Tyrphostin A9 can be used for inhibiting tyrosine kinase functions in C2C12 cells. It has also been used to disrupt membrane potential in mammalian cells.

Uses

SF 6847 is an inhibitor of EGFR with IC50 of 460 μM.

Uses

Selective inhibitor of PDGF receptor tyrosine kinase

Definition

ChEBI: Malonoben is an alkylbenzene. It has a role as a geroprotector.

General Description

A selective, cell-permeable, reversible, and substrate competitive inhibitor of the platelet-derived growth factor receptor tyrosine kinase (IC₅₀ = 500 nM). Anti-proliferative agent. Uncoupler of oxidative phosphorylation. Induces apoptosis in vitro and cell growth arrest in NHL cell lines.

Biological Activity

Potent uncoupler of oxidative phosphorylation.

Biochem/physiol Actions

Cell permeable: yes

References

1) Bilder?et al. (1991),?Tyrphostins inhibit PDGF-induced DNA synthesis and associated early events in smooth muscle cells; Am. J. Physiol.,?260?C721 2) Terada?et al. (1981),?The interaction of highly active uncouplers with mitochondria; Biochim. Biophys. Acta,?639?225 3) Burger?et al. (1995),?Tyrphostin AG17, [3,5-Ditert-butyl-4-hydroxybenzylidene)-malononitrile], inhibits cell growth by disrupting mitochondria; Cancer Res.,?55?2794 4) Thyberg?et al. (1998),?Tyrphostin A9 and wortmannin perturb the Golgi complex and block proliferation of vascular smooth muscle cells; Eur. J. Cell Biol.,?76?33

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