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DMT-2'-O-MOE-rU Phosphoramidite

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DMT-2'-O-MOE-rU Phosphoramidite Basic information

Product Name:
DMT-2'-O-MOE-rU Phosphoramidite
Synonyms:
  • (2R,3R,4R,5R)-2-((BIS(4-METHOXYPHENYL)(PHENYL)METHOXY)METHYL)-5-(2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)-4-(2-METHOXYETHOXY)TETRAHYDROFURAN-3-YL 2-CYANOETHYL DIISOPROPYLPHOSPHORAMIDITE
  • 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)uridine 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]
  • 5'-O-DMTr-2'-O-(2-methoxyethyl)-uridine-3'-CED-phosphoramidite
  • 5'-O-DMT-2'-O-(2-methoxyethyl)uridine 3'-CE phosphoramidite
  • 2'-O-MOE-U-CE Phosphoramidite
  • 2'-O-MOE-U-3'-phosphoramidite
  • 2'-O-MOE-U Phosphoramidite
  • Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite] (9CI)
CAS:
163759-97-5
MF:
C42H53N4O10P
MW:
804.86
Product Categories:
  • Phosphoramidite
Mol File:
163759-97-5.mol
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DMT-2'-O-MOE-rU Phosphoramidite Chemical Properties

storage temp. 
4°C, protect from light
form 
Solid
pka
9.39±0.10(Predicted)
color 
White to off-white
InChI
InChI=1/C42H53N4O10P/c1-29(2)46(30(3)4)57(54-25-11-23-43)56-38-36(55-40(39(38)52-27-26-49-5)45-24-22-37(47)44-41(45)48)28-53-42(31-12-9-8-10-13-31,32-14-18-34(50-6)19-15-32)33-16-20-35(51-7)21-17-33/h8-10,12-22,24,29-30,36,38-40H,11,25-28H2,1-7H3,(H,44,47,48)/t36-,38-,39-,40-,57?/s3
InChIKey
ZLOKLUONKGURQI-LWTSSKLSNA-N
SMILES
O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@H](OCCOC)[C@@H]1OP(N(C(C)C)C(C)C)OCCC#N |&1:25,27,36,42,r|
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DMT-2'-O-MOE-rU Phosphoramidite Usage And Synthesis

Description

2'-O-MOE-U-3'-phosphoramidite (DMT-2'-O-MOE-rU Phosphoramidite) is a 2'-O-MOE-protected nucleoside phosphoramidite that can be inserted into oligonucleotide phosphoramidites for antisense RNA. The 2'-MOE backbone enhances stability, resists nuclease, and exhibits low toxicity for improved genetic manipulation.

Chemical Properties

White to Light yellow powder to crystal

DMT-2'-O-MOE-rU PhosphoramiditeSupplier

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