Pemetrexed disodium hemipentahydrate Chemical Properties

Melting point:

274-276°C (dec.)

storage temp. 

Room Temperature

solubility 

DMSO, Methanol, Water

form 

Solid

color 

Off-White

InChIKey

AEZRDYKQLPDYEH-YTCXBBKHNA-N

SMILES

C(C1=CNC2NC(N)=NC(=O)C1=2)CC1C=CC(C(=O)N[C@H](C(=O)O)CCC(=O)O)=CC=1.[NaH].O |&1:20,r|

CAS DataBase Reference

357166-30-4(CAS DataBase Reference)

Safety Information

WGK Germany 

WGK 3

Storage Class

6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

Hazard Classifications

Eye Irrit. 2
Muta. 2
Repr. 1A
Skin Irrit. 2
STOT RE 1

Pemetrexed disodium hemipentahydrate Usage And Synthesis

Uses

Pemetrexed Disodium Hydrate is an chemotherapy drug for the treatment of pleural mesothelioma and non-small cell lung cancer. Pemetrexed Disodium Hydrate exhibit inhibitory activities towards thymidylate synthase as well as other folate dependent enzymes.

brand name

Pemetrexed is a chemotherapy drug that is manufactured and marketed by Eli Lilly and Company under the brand name Alimta.

Mechanism of action

Pemetrexed disodium hemipentahydrate stops cells from using folic acid to make DNA and may kill cancer cells.

in vivo

The group of mice treated with PC61 plus Pemetrexed demonstrates statistically longer survival than other groups. In a survival analysis, significantly better survival is observed in the group of mice treated with PC61 plus Pemetrexed compare with those treated with PC61 alone, rat IgG plus Pemetrexed, or no treatment.

Pemetrexed disodium hemipentahydrate(357166-30-4)Related Product Information

• Pemetrexed Disodium Heptahydrate
• 4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pymol[2,3-d]pyrimodin-5-yl)ethyl]benzoic acid
• Pemetrexed Disodium
• Pemetrexed