ChemicalBook > Product Catalog > Biochemical Engineering > Amino Acids and Derivatives > Glutamic acid derivatives > Pemetrexed disodium hemipentahydrate
Pemetrexed disodium hemipentahydrate
Pemetrexed disodium hemipentahydrate Basic information
- Product Name:
- Pemetrexed disodium hemipentahydrate
- Synonyms:
-
- N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid disodium salt hydrate
- PeMetrexed sodiuM hydrate (1:2:2.5)
- Pemetrexed disodium hydrate
- PeMetrexed DisodiuM heMipenta hydrate
- Pemetrexed disodium 2.5 hydrate
- PeMetrexed (disodiuM heMipenta hydrate) (1:2:2.5)
- L-GlutaMic acid,N-[4-[2-(2-aMino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoyl]-,sodiuM salt, hydrate (2:4:5) (9CI)
- LY-231514 Disodium Hydrate
- CAS:
- 357166-30-4
- MF:
- C20H24N5NaO7
- MW:
- 469.43
- EINECS:
- 814-356-7
- Product Categories:
-
- Inhibitors
- Anti-cancer&immunity
- API
- 357166-30-4
- Mol File:
- 357166-30-4.mol
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Pemetrexed disodium hemipentahydrate Chemical Properties
- Melting point:
- 274-276°C (dec.)
- storage temp.
- Room Temperature
- solubility
- DMSO, Methanol, Water
- form
- Solid
- color
- Off-White
- InChIKey
- AEZRDYKQLPDYEH-YTCXBBKHNA-N
- SMILES
- C(C1=CNC2NC(N)=NC(=O)C1=2)CC1C=CC(C(=O)N[C@H](C(=O)O)CCC(=O)O)=CC=1.[NaH].O |&1:20,r|
- CAS DataBase Reference
- 357166-30-4(CAS DataBase Reference)
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Pemetrexed disodium hemipentahydrate Usage And Synthesis
Uses
Pemetrexed Disodium Hydrate is an chemotherapy drug for the treatment of pleural mesothelioma and non-small cell lung cancer. Pemetrexed Disodium Hydrate exhibit inhibitory activities towards thymidylate synthase as well as other folate dependent enzymes.
in vivo
The group of mice treated with PC61 plus Pemetrexed demonstrates statistically longer survival than other groups. In a survival analysis, significantly better survival is observed in the group of mice treated with PC61 plus Pemetrexed compare with those treated with PC61 alone, rat IgG plus Pemetrexed, or no treatment[2].
Pemetrexed disodium hemipentahydrateSupplier
Guangzhou Tomums Life Science Co., Ltd. Gold
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Fujian South Pharmaceutical Co., Ltd. Gold
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