OPHIOPOGONIN D Chemical Properties

Density 

1.40

solubility 

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

form 

Powder

pka

12.78±0.70(Predicted)

color 

White to off-white

OPHIOPOGONIN D Usage And Synthesis

Chemical Properties

White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Ophiopogon japonicus.

Uses

Ophiopogonin D', isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C29 steroidal glycoside. Ophiopogonin D' shows cytotoxic activity against two human tumor cell lines MG-63 and SNU387 with IC50s of 3.09 μM and 3.63 μM, respectively[1]. Ophiopogonin D' activates SIRT1 in a dose-dependent manner[2].

Biological Activity

Ophiopogonin D, isolated from the tuber of Ophiopogon japonicus, is a rare naturally occurring C29 steroidal glycoside. Ophiopogonin D' has cytotoxic activity against two human tumor cell lines, MG-63 and SNU387, with IC50s of 3.09 μM and 3.63 μM, respectively.

target

IC 50

SIRT1

References

[1] Wang L , et al. Homo-aro-cholestane, furostane and spirostane saponins from the tubers of Ophiopogonjaponicus. Phytochemistry. 2017 Apr;136:125-132. DOI:10.1016/j.phytochem.2017.01.006
[2] Wang Y, et al. Specific Turn-On Fluorescent Probe with Aggregation-Induced EmissionCharacteristics for SIRT1 Modulator Screening and Living-Cell Imaging. Anal Chem. 2015;87(10):5046-9. DOI:10.1021/acs.analchem.5b01069

OPHIOPOGONIN D(65604-80-0)Related Product Information

• OPHIOPOGONIN D
• OPHIOPOGONIN C
• Methylophiopogonone A
• Celosin K
• Epigomisin O
• Benzoylgomisin O
• Ophiopogonin A
• Celosin H
• Glycoside O-4
• Methylophiopogonanone B
• (6S,7S,12aR)-5,6,7,8-Tetrahydro-2,3,10,11,12-pentamethoxy-6,7-dimethyldibenzo[a,c]cyclooctene-1,7-diol
• Methylophiopogonanone A
• Liriopeside B
• RUSCOGENIN
• 27-Hydroxycholesterol
• Diosgenin
• 22(R)-HYDROXYCHOLESTEROL
• OPHIOPOGONIN D