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3-(3,4-Difluorobenzoyl)-1,2,3,6-tetrahydro-1,1-dimethylazepino[4,5-b]indole-5-carboxylic acid 1-methylethyl ester

Basic information Safety Supplier Related

3-(3,4-Difluorobenzoyl)-1,2,3,6-tetrahydro-1,1-dimethylazepino[4,5-b]indole-5-carboxylic acid 1-methylethyl ester Basic information

Product Name:
3-(3,4-Difluorobenzoyl)-1,2,3,6-tetrahydro-1,1-dimethylazepino[4,5-b]indole-5-carboxylic acid 1-methylethyl ester
Synonyms:
  • 3-(3,4-Difluorobenzoyl)-1,2,3,6-tetrahydro-1,1-dimethylazepino[4,5-b]indole-5-carboxylic acid 1-methylethyl ester
  • Fxr 450
  • Turofexorate isopropyl
  • isopropyl 3-(3,4-difluorobenzoyl)-1,1-dimethyl-1,2,3,4,5,5a,6,10b-octahydroazepino[4,5-b]indole-5-carboxylate
  • XL335;TUROFEXORATE ISOPROPYL
  • CS-899
  • XL335; WAY 362450; TUROFEXORATE ISOPROPYL; WAY-362450
  • Turofexorate isopropyl [usan]
CAS:
629664-81-9
MF:
C25H24F2N2O3
MW:
438.47
Product Categories:
  • Inhibitors
  • A farnesoid X receptor (FXR) agonist .
Mol File:
629664-81-9.mol
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3-(3,4-Difluorobenzoyl)-1,2,3,6-tetrahydro-1,1-dimethylazepino[4,5-b]indole-5-carboxylic acid 1-methylethyl ester Chemical Properties

Boiling point:
617.3±55.0 °C(Predicted)
Density 
1.275
storage temp. 
room temp
solubility 
DMSO : 25 mg/mL (57.02 mM; Need ultrasonic)
pka
16.49±0.60(Predicted)
form 
powder
color 
white to beige
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3-(3,4-Difluorobenzoyl)-1,2,3,6-tetrahydro-1,1-dimethylazepino[4,5-b]indole-5-carboxylic acid 1-methylethyl ester Usage And Synthesis

Definition

ChEBI: Turofexorate isopropyl is a member of indoles.

Biochem/physiol Actions

WAY-362450 is a potent and selective Farnesoid X receptor (FXR) agonist that lowers total plasma cholesterol (all lipoprotein species). WAY-362450 reduced the levels of high-density lipoprotein cholesterol (HDLc) in Cynomolgus monkeys, mice and hamsters. Apparently HDL lowering is achieved through increased transhepatic cholesterol efflux.

3-(3,4-Difluorobenzoyl)-1,2,3,6-tetrahydro-1,1-dimethylazepino[4,5-b]indole-5-carboxylic acid 1-methylethyl esterSupplier

Shanghaizehan biopharma technology co., Ltd. Gold
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021-61350663 13052117465
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sales@zehanbiopharma.com
Shanghai Boyle Chemical Co., Ltd.
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Chembest Research Laboratories Limited
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+86-21-20908456
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VDM Biochemicals
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0330-2528181
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Dalian Meilun Biotech Co., Ltd.
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0411-62910999 13889544652
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3-(3,4-Difluorobenzoyl)-1,2,3,6-tetrahydro-1,1-dimethylazepino[4,5-b]indole-5-carboxylic acid 1-methylethyl ester(629664-81-9)Related Product Information