3-(3,4-Difluorobenzoyl)-1,2,3,6-tetrahydro-1,1-dimethylazepino[4,5-b]indole-5-carboxylic acid 1-methylethyl ester
3-(3,4-Difluorobenzoyl)-1,2,3,6-tetrahydro-1,1-dimethylazepino[4,5-b]indole-5-carboxylic acid 1-methylethyl ester Basic information
- Product Name:
- 3-(3,4-Difluorobenzoyl)-1,2,3,6-tetrahydro-1,1-dimethylazepino[4,5-b]indole-5-carboxylic acid 1-methylethyl ester
- Synonyms:
-
- 3-(3,4-Difluorobenzoyl)-1,2,3,6-tetrahydro-1,1-dimethylazepino[4,5-b]indole-5-carboxylic acid 1-methylethyl ester
- Fxr 450
- Turofexorate isopropyl
- isopropyl 3-(3,4-difluorobenzoyl)-1,1-dimethyl-1,2,3,4,5,5a,6,10b-octahydroazepino[4,5-b]indole-5-carboxylate
- XL335;TUROFEXORATE ISOPROPYL
- CS-899
- XL335; WAY 362450; TUROFEXORATE ISOPROPYL; WAY-362450
- Turofexorate isopropyl [usan]
- CAS:
- 629664-81-9
- MF:
- C25H24F2N2O3
- MW:
- 438.47
- Product Categories:
-
- Inhibitors
- A farnesoid X receptor (FXR) agonist .
- Mol File:
- 629664-81-9.mol
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3-(3,4-Difluorobenzoyl)-1,2,3,6-tetrahydro-1,1-dimethylazepino[4,5-b]indole-5-carboxylic acid 1-methylethyl ester Chemical Properties
- Boiling point:
- 617.3±55.0 °C(Predicted)
- Density
- 1.275
- storage temp.
- room temp
- solubility
- DMSO : 25 mg/mL (57.02 mM; Need ultrasonic)
- pka
- 16.49±0.60(Predicted)
- form
- powder
- color
- white to beige
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3-(3,4-Difluorobenzoyl)-1,2,3,6-tetrahydro-1,1-dimethylazepino[4,5-b]indole-5-carboxylic acid 1-methylethyl ester Usage And Synthesis
Definition
ChEBI: Turofexorate isopropyl is a member of indoles.
Biochem/physiol Actions
WAY-362450 is a potent and selective Farnesoid X receptor (FXR) agonist that lowers total plasma cholesterol (all lipoprotein species). WAY-362450 reduced the levels of high-density lipoprotein cholesterol (HDLc) in Cynomolgus monkeys, mice and hamsters. Apparently HDL lowering is achieved through increased transhepatic cholesterol efflux.
3-(3,4-Difluorobenzoyl)-1,2,3,6-tetrahydro-1,1-dimethylazepino[4,5-b]indole-5-carboxylic acid 1-methylethyl esterSupplier
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