Cd135 Chemical Properties

storage temp. 

-70°C

form 

buffered aqueous solution

biological source

rabbit

Specific Activity

60-81nmol/min·mg

Safety Information

Hazard Codes 

Xn,T

Risk Statements 

22-61-52/53

Safety Statements 

53-45-61

Cd135 Usage And Synthesis

Uses

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Definition

ChEBI: Cadmium atom is a zinc group element atom.

General Description

Aquanal^? kits can be used for the determination of hardness and phosphate ammonia, nitrate, and nitrite concentrations.

Biological Activity

FLT3 (fms-related tyrosine kinase 3), upon interaction with its ligand, undergoes conformational changes to form homodimers. This results in phosphorylation and activation of downstream signaling pathways including phosphatidylinositol 3-kinase (PI3K/AKT), mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) and signal transducer and activator of transcription 5 (STAT5) pathways. Internal tandem duplication (ITD) mutation or a point mutation in juxtamembrane domain-coding region or within the activation loop domain, respectively, of this gene lead to its constitutive action. FLT3/ITD mutation is associated with later stages of acute myeloid leukemia (AML) pathogenesis. These patients have poor prognosis.

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