MK-5172
MK-5172 Basic information
- Product Name:
- MK-5172
- Synonyms:
-
- MK-5172
- (1aR,5S,8S,10R,22aR)-5-(1,1-Dimethylethyl)-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-14-methoxy-3,6-dioxo-8H-7,10-methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxylic acid
- 8H-7,10-Methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxylic acid, 5-(1,1-diMethylethyl)-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-14-Methoxy-3,6-dioxo-,(1aR,5S,8S,10R,22aR)-
- (1aR,5S,8R,10S,22aR)-5-tert-butyl-14-methoxy-3,6-dioxo-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-8H-7,10-methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxylic acid
- Grazoprevir Intermediate 5
- (33R,35S,91R,92R,5S)-5-(tert-butyl)-17-methoxy-4,7-dioxo-2,8-dioxa-6-aza-1(2,3)-quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopropanacyclotetradecaphane-35-carboxylicacid
- (1aR,5S,8S,10R,22aR)-5-tert-butyl-14-methoxy-3,6-dioxo-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-8H-7,10-methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxylic acid
- MK-5172 intermidiate
- CAS:
- 1206524-85-7
- MF:
- C29H38N4O7
- MW:
- 554.63
- EINECS:
- 943-551-0
- Product Categories:
-
- intermediates
- MK-5172 intermediate
- Mol File:
- 1206524-85-7.mol
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MK-5172 Chemical Properties
- Melting point:
- 180-185oC
- Boiling point:
- 825.0±65.0 °C(Predicted)
- Density
- 1.33
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- Acetone (Slightly), Chloroform (Slightly), DMSO (Slightly, Sonicated), Methanol
- form
- Solid
- pka
- 3.23±0.40(Predicted)
- color
- White to Off-White
- Stability:
- Hygroscopic
- InChIKey
- IVROMYPOGKZNLP-FDOFPDFBSA-N
- SMILES
- N1C2C(=CC=C(OC)C=2)N=C2CCCCC[C@]3([H])C[C@@]3([H])OC(=O)N[C@@H](C(C)(C)C)C(=O)N3C[C@]([H])(OC=12)C[C@H]3C(O)=O
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MK-5172 Usage And Synthesis
Uses
MK-5172 is a selective inhibitor of hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants.
Advantages
MK-5172 has a higher barrier to resistance than first-generation protease inhibitors and is active against most variants associated with resistance to first-generation protease inhibitors. Tolerability and safety profile are good.
MK-5172Supplier
Shanghai Boyle Chemical Co., Ltd.
- Tel
- sales@boylechem.com
ZHIWE CHEMTECH CO LTD
- Tel
- 021-20221225 13917446399
- zwchem@163.com
Synches Co., Ltd.
- Tel
- 021-53292253
- biz@synches.com
BOC Sciences
- Tel
- 1-631-485-4226; 16314854226
- info@bocsci.com
Shanghai T&W Pharmaceutical Co., Ltd.
- Tel
- +86 21 61551611