Acotiamide Hydrochloride Chemical Properties

storage temp. 

Sealed in dry,Store in freezer, under -20°C

Acotiamide Hydrochloride Usage And Synthesis

Description

Acotiamide Hydrochloride (YM-443, Z-338) is the hydrochloride salt form of acotiamide, a prokinetic agent with gastrointestinal (GI) motility-enhancing activity. It is a new orally active selective acetylcholinesterase inhibitor. Although the exact mechanism by which acotiamide exerts its effect has yet to be fully elucidated, this agent appears to inhibit acetylcholinesterase (AchE), an enzyme responsible for the breakdown of acetylcholine (Ach). Increased Ach concentrations lead to an improvement of gastric emptying and GI motility and eventually to a reduction of dyspepsia symptoms.

Uses

Acotiamide Hydrochloride is an acetylcholinesterase inhibitor which has been shown to stimulate gastric motility and improve gastric motility dysfunction in rats (1,2). Acotiamide Hydrochloride has also been shown to improve meal-related symptoms of functional dyspepsia.

Biological Activity

Acotiamide hydrochloride is an orally active, selective and reversible acetylcholinesterase (AChE) inhibitor, with an IC50 of 1.79 μM. Acotiamide hydrochloride can enhance gastric contractility and accelerate delayed gastric emptying. Acotiamide hydrochloride has the potential for the research of functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory.

Acotiamide Hydrochloride(185104-11-4)Related Product Information

• 2-Aminothiazole-4-carboxylic acid
• Methyl 2-Aminothiazole-4-carboxylate
• Ethyl bromopyruvate
• AcotiaMide IMpurity 9
• AcotiaMide Related CoMpound 6
• Acotiamide Impurity 27
• Acotiamide INT
• AcotiaMide related coMpound 2
• AcotiaMide IMpurity 7
• AcotiaMide iMpurity 5
• Acotiamide Impurity 40
• Acotiamide Impurity 30
• Acotiamide Impurity 15
• Acotiamide Hydrochloride
• AcotiaMide iMpurity 1
• 2,4,5-TRIHYDROXYBENZOIC ACID
• Acotiamide Impurity 10 HCl
• Acotiamide Impurity 21