7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol
7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol Basic information
- Product Name:
- 7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol
- Synonyms:
-
- 7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol
- WAY 200070
- 7-bromo-2-(4-hydroxyphenyl)-5-benzoxazolol
- WAY200070;WAY 200070
- 5-Benzoxazolol, 7-bromo-2-(4-hydroxyphenyl)-
- 7-Bromo-2-(4-hydroxyphenyl)benzo[d]oxazol-5-ol
- Estrogen Receptor/ERR,WAY200070,WAY-200070,Inhibitor,inhibit
- CAS:
- 440122-66-7
- MF:
- C13H8BrNO3
- MW:
- 306.11
- EINECS:
- 604-604-1
- Mol File:
- 440122-66-7.mol
7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol Chemical Properties
- Boiling point:
- 463.6±35.0 °C(Predicted)
- Density
- 1.720±0.06 g/cm3(Predicted)
- storage temp.
- Store at RT
- solubility
- DMSO: ≥20mg/mL
- form
- solid
- pka
- 7.26±0.40(Predicted)
7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol Usage And Synthesis
Uses
WAY 200070 is an aryl diphenolic azole and a selective ERβ agonist. This compound is suitable for estrogen receptor signaling research.
Biological Activity
WAY-200070 is a selective estrogen receptor agonist with IC50 of 2.3 nM.
in vivo
Administration of WAY-200070 (30 mg/kg sc) causes nuclear translocation of ERRβ receptors in WT mice. Administration of it produces a delayed 50% increase in dopamine in the striatum of wild type mice. It reduces immobility time in the mouse tail suspension test indicating an antidepressant-like effect. In gonadally intact male and female mice WAY-200070 increases agonistic behaviors such as pushing down and aggressive grooming, while leaving attacks unaffected. Ovariectomized (ovx) mice treated with PPT fail to learn the socially acquired preference, while WAY-200070-treated ovx mice shows a two-fold prolonged preference for the food eaten by their demonstrator. WAY-200070 , shows significantly decreased anxiety-like behaviors in both the open-field and elevated plus maze and significantly less depressive-like behaviors in the forced swim test.
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target
IC50: 2.3 nM (ERRβ), 155 nM (ERRα)
7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-olSupplier
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- 022-23989838 13810451150
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- 821-50328103-801 18930552037
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- 021-52996696，15000506266 15000506266
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