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(3alpha,4beta)-3-(Acetyloxy)olean-12-en-23-oic acid

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(3alpha,4beta)-3-(Acetyloxy)olean-12-en-23-oic acid Basic information

Product Name:
(3alpha,4beta)-3-(Acetyloxy)olean-12-en-23-oic acid
Synonyms:
  • (3alpha,4beta)-3-(Acetyloxy)olean-12-en-23-oic acid
  • Acetyl-alpha-boswellic acid
  • alpha-Boswellic acid acetate
  • 3-O-Acetyl-alpha-boswellic acid
  • (3α,4β)-3-(Acetyloxy)olean-12-en-23-oic acid
  • 3α-(Acetyloxy)olean-12-en-24-oic acid
  • Boswellic Acid Impurity 1
  • Olean-12-en-23-oic acid, 3-(acetyloxy)-, (3α,4β)-
CAS:
89913-60-0
MF:
C32H50O4
MW:
498.74
Mol File:
89913-60-0.mol
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(3alpha,4beta)-3-(Acetyloxy)olean-12-en-23-oic acid Chemical Properties

Melting point:
230-232℃
Boiling point:
563.6±50.0 °C(Predicted)
Density 
1.10
storage temp. 
Refrigerator
solubility 
Chloroform (Slightly)
form 
Solid
pka
4.32±0.70(Predicted)
color 
White to Off-White
LogP
10.320 (est)
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Safety Information

WGK Germany 
3
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(3alpha,4beta)-3-(Acetyloxy)olean-12-en-23-oic acid Usage And Synthesis

Description

α-acetyl Boswellic acid is a pentacyclic triterpene and isomer of β-acetyl-boswellic acid originally isolated from B. serrata. It inhibits LPS-induced TNF-α mRNA expression in monocytes as well as NF-κB activity in HEK293 cells when used at a concentration of 10 μM. α-acetyl Boswellic acid also inhibits phosphorylation of IκBα mediated by IκB kinases (IKKs) in monocytes.

Uses

Acetyl-α-boswellic Acid is a selective inhibitor of COX-1. It also inhibits NF-KB signaling in LPS-stimulated monocytes.

Definition

ChEBI: 3-alpha-O-acetyl-alpha-boswellic acid is a triterpenoid. It has a role as a metabolite.

target

PGE

(3alpha,4beta)-3-(Acetyloxy)olean-12-en-23-oic acidSupplier

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