CP 945598 hydrochloride
CP 945598 hydrochloride Basic information
- Product Name:
- CP 945598 hydrochloride
- Synonyms:
-
- 1-[9-(4-Chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl]-4-ethylaminopiperidine-4-carboxylic acid amide hydrochloride
- CP-945598 HCl, >=99%
- CP 945598 hydrochloride
- 1-[8-(2-Chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]- 4-(ethylaMino)-4-piperidinecarboxaMide Monohydrochloride
- 1-[8-(2-Chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-4-(ethylaMino)-4-piperidinecarboxaMide Hydrochloride
- CP 945
- 4-PiperidinecarboxaMide, 1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-4-(ethylaMino)-, (Hydrochloride) (1:1)
- Otenabant (Hydrochloride)
- CAS:
- 686347-12-6
- MF:
- C25H26Cl3N7O
- MW:
- 546.87924
- Product Categories:
-
- Inhibitors
- Amines
- Aromatics
- Heterocycles
- Intermediates & Fine Chemicals
- Pfizer Compounds
- Pharmaceuticals
- Mol File:
- 686347-12-6.mol
CP 945598 hydrochloride Chemical Properties
- Melting point:
- 275-276℃ (decomposition)
- storage temp.
- room temp
- solubility
- DMSO: soluble1mg/mL, clear (warmed)
- form
- powder
- color
- white to beige
CP 945598 hydrochloride Usage And Synthesis
Chemical Properties
Off-White Solid
Uses
CP 945598 is a selective, high affinity CB1 antagonist (Ki values are 0.7 and 0.12 nM in binding and functional assays respectively). Displays low affinity for CB2 receptors (Ki = 7600 nM).
Biological Activity
CP-945,598 is a potent, selective, high affinity and competitive cannabinoid type 1 (CB1) receptor antagonist. CP-945,598 inhibits both basal and cannabinoid agonist-mediated CB1 receptor signaling in vitro and in vivo. CP-945,598 exhibits anorectic activity in two models of acute food intake in rodents, fast-induced re-feeding and spontaneous, nocturnal feeding.', 'CP-945,598 is also known as 1-(8-(2-Chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl)-4-(ethylamino)piperidine-4-carboxamide. This orally active antagonist of the cannabinoid CB-1 receptor may be used in the treatment of obesity.
in vivo
Otenabant acutely stimulates energy expenditure in rats and decreases the respiratory quotient indicating a metabolic switch to increased fat oxidation. Otenabant (10 mg/kg, p.o.) promotes a 9%, vehicle adjusted weight loss in a 10 day weight loss study in diet-induced obese mice[1]. Otenabant HCl reverses four cannabinoid agonistmediated behaviors (locomotor activity, hypothermia, analgesia, and catalepsy) following administration of the synthetic CB1 receptor agonist CP-55940. Otenabant HCl exhibits dose-dependent anorectic activity in a model of acute food intake in rodents and increased energy expenditure and fat oxidation[2].
storage
Store at +4°C
CP 945598 hydrochlorideSupplier
- Tel
- sales@boylechem.com
- Tel
- 18210857532; 18210857532
- jkinfo@jkchemical.com
- Tel
- 021-50135380
- shchemsky@sina.com
- Tel
- 0411-62910999 13889544652
- sales@meilune.com
- Tel
- 400-6206333 13167063860
- anhua.mao@aladdin-e.com