methyl morpholine-2-carboxylate hydrochloride Chemical Properties

storage temp. 

Inert atmosphere,Room Temperature

Appearance

White to off-white Solid

Safety Information

RIDADR 

UN2811

HS Code 

2934999090

methyl morpholine-2-carboxylate hydrochloride Usage And Synthesis

Uses

Methyl Morpholine-2-carboxylate Hydrochloride is used as a preparation of chromen-4-one derivative for the treatment of hepatitis B virus infection.

Synthesis

The general procedure for the synthesis of methyl morpholine-2-carboxylate hydrochloride from methyl N-Boc-2-morpholinecarboxylate was as follows: to a solution of 1,4-dioxane (1.0 mL) containing methyl 4-(tert-butoxycarbonyl)-2-morpholinecarboxylate (232 mg, 0.95 mmol) was added a solution of 1,4-dioxane (1.18 mL) with 4 M hydrochloric acid. The reaction mixture was stirred at room temperature for 15 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure to afford methyl morpholine-2-carboxylate hydrochloride (232 mg, 0.95 mmol, quantitative yield). The structure of the product was confirmed by 1H NMR (CDCl3) with the following chemical shifts: δ 3.03-3.19 (2H, m), 3.26-3.45 (2H, m), 3.55-3.69 (1H, m), 3.82 (3H, s), 4.03-4.22 (2H, m), 4.58-4.69 (1H, m).

References

[1] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 9, p. 3072 - 3093

methyl morpholine-2-carboxylate hydrochloride(937063-34-8)Related Product Information

• Diphenhydramine
• MORPHOLIN-4-YL-ACETIC ACID
• Morpholine-2-carbonitrile hydrochloride
• Methyl Morpholine-3-carboxylate-HCl
• 2-Morpholinecarboxylicacid,methylester(9CI)
• MORPHOLINE-4-SULFONYL CHLORIDE
• MORFOLINE METHYLCARBAMATE
• Morpholinazole
• 2-MORPHOLINEACETIC ACID
• 2-CARBOXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER
• (S)-2-(Methoxymethyl)morpholine HCl
• (S)-methyl morpholine-2-carboxylate hydrochloride
• (R)-2-Morpholineacetic acid
• (S)-N-Boc-Morpholine-2-acetic acid
• 2-(Methoxymethyl)morpholine HCl
• (R)-2-(Methoxymethyl)morpholine HCl
• (R)-N-Boc-Morpholine-2-acetic acid
• (R)-methyl morpholine-2-carboxylate hydrochloride