Basic information Safety Supplier Related

Peramivir Trihydrate

Basic information Safety Supplier Related

Peramivir Trihydrate Basic information

Product Name:
Peramivir Trihydrate
Synonyms:
  • Peramivir Trihydrate
  • BCX 1812 trihydrate
  • Rapiacta trihydrate
  • RWJ 270201 trihydrate
  • (1S,2S,3R,4R)-3-[(1S)-1-(Acetylamino)-2-ethylbutyl]-4-[(aminoiminomethyl)amino]-2-hydroxycyclopentanecarboxylic acid hydrate
  • PeraMivir trihydrate/3(R)-[1(S)-AcetaMido-2-ethylbutyl]-4(R)-guanidino-2(S)-hydroxycyclopentane-1(S)-carboxylic acid
  • PeraMivir Hydrate
  • eraMivir
CAS:
1041434-82-5
MF:
C15H30N4O5
MW:
346.43
EINECS:
1308068-626-2
Product Categories:
  • Inhibitors
  • API
  • 1041434-82-5
Mol File:
1041434-82-5.mol
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Peramivir Trihydrate Chemical Properties

storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
H2O : 6.6 mg/mL (17.26 mM; Need ultrasonic)
form 
Powder
color 
White to off-white
InChIKey
DLIKIAYLVAIOME-KAJZLETJNA-N
SMILES
[C@H]([C@]1([H])[C@@H]([C@@H](C(=O)O)C[C@H]1NC(N)=N)O)(NC(=O)C)C(CC)CC.O |&1:0,1,3,4,9,r|
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Peramivir Trihydrate Usage And Synthesis

Uses

Peramivir Trihydrate is a trihydrate of the anti-infection agent Peramivir Trihydrate which is a transition-state analogue and a potent, specific influenza viral neuraminidase inhibitor with an IC50 of median 0.09 nM.[1] The IC50 for Peramivir Trihydrate

Definition

ChEBI: A hydrate that is the trihydrate form of peramivir. Used for the treatment of acute uncomplicated influenza in patients 18 years and older who have been symptomatic for no more than two days.

in vitro

Peramivir trihydrate (0.3125-40 μM, 4 h) has nontoxicity to macrophage.
Peramivir trihydrate (2-10 μM, 6-12 h) inhibits cytokine release in LPS-induced hPBMCs.

in vivo

Peramivir trihydrate (20-60 mg/kg, i.p., single dose) inhibits LPS-induced cytokine storm, attenuates acute lung injury and prolongs the survival in cytokine storm syndrome model mice.
Peramivir trihydrate (75 mg/kg, i.m., once a day for 7 days) rescued BALB scid mice from lethal challenge with BR/08 in immunocompromised murine models of infuenza B virus infection.

Peramivir TrihydrateSupplier

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