2'-Azido-2'-deoxy-5-methyluridine
2'-Azido-2'-deoxy-5-methyluridine Basic information
- Product Name:
- 2'-Azido-2'-deoxy-5-methyluridine
- Synonyms:
-
- 1-[3-AZIDO-4-HYDROXY-5-(HYDROXYMETHYL)OXOLAN-2-YL]-5-METHYL-3H-PYRIMIDINE-2,4-DIONE
- 1-(2'-azido-2'-deoxy-β-β-D-ribofuranosyl)thymine
- 2'-Azido-2'-deoxy-5-methyluridine
- 2’-Azido-2’-deoxy-5-methyluridine
- Uridine, 2′-azido-2′-deoxy-5-methyl-
- CAS:
- 97748-75-9
- MF:
- C10H13N5O5
- MW:
- 283.24
- Mol File:
- 97748-75-9.mol
2'-Azido-2'-deoxy-5-methyluridine Usage And Synthesis
Uses
2′-Azido-2′-deoxy-5-methyluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 2′-Azido-2′-deoxy-5-methyluridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
References
[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005
2'-Azido-2'-deoxy-5-methyluridineSupplier
- Tel
- 021-61551611 13296011611
- contact@trustwe.com
- Tel
- 0371-85513397
- info@granlen.com
- Tel
- info@creative-peptides.com
- Tel
- 571-89925085
- sales@amadischem.com
- Tel
- 021-36680027/1762825045
- sales2@elestone.com.cn