MPEG12-Mal Chemical Properties

storage temp. 

-20°C

form 

solid or viscous liquid

MPEG12-Mal Usage And Synthesis

Description

m-PEG12-Mal is a PEG linker containing a maleimide group. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The hydrophilic PEG spacer increases solubility in aqueous media.

Uses

Mal-PEG-OH (MW 5000) can be used as a macroinitiator to obtain amphiphilic diblock copolymers by ring-opening polymerization of LA. Nanoparticles prepared using amphiphilic block copolymers can form active drug delivery systems. Nanoparticles encapsulate Triptolide (HY-32735), which can avoid the disadvantage of Triptolide’s poor water solubility and reduce its toxicity.

reaction suitability

reagent type: chemical modification reagent
reagent type: cross-linking reagent
reactivity: sulfhydryl reactive
reagent type: linker
reactivity: thiol reactive

References

[1] Chen XY, et al. The potential of follicle-stimulating hormone peptide-modified triptolide-loaded nanoparticles to induce a mouse model of premature ovarian insufficiency. Int J Nanomedicine. 2015 Apr 7;10:2765-74. DOI:10.2147/IJN.S72593

MPEG12-Mal(88504-24-9)Related Product Information

• HO-PEG-NH2
• 13-Azido-2,5,8,11-tetraoxa-tridecane
• MPEG8-NH-Mal
• MPEG4-NHS
• m-PEG8-NHS ester
• MPEG5-NHS
• mPEG11-CH2COOH
• alpha-aMine-oMega-propionic acid hexaethylene glycol
• PEG-Azide, O-(2-Azidoethyl)-Oμ-methylpolyethylene glycol
• 3,6,9-trioxaundecamethylenediamine
• Propargyl-PEG5-alcohol
• MPEG3-NHS
• MPEG11-NHS
• m-PEG12-OTs
• MPEG12-N3
• MPEG11-CH2CH2COOH
• MPEG12-NH2
• 3,6,9,12,15,18,21,24,27,30,33,36-Dodecaoxaheptatriacontane-1-thiol