4-METHYLUMBELLIFERYL-ALPHA-D-GLUCOPYRANOSIDE HYDRATE
4-METHYLUMBELLIFERYL-ALPHA-D-GLUCOPYRANOSIDE HYDRATE Basic information
- Product Name:
- 4-METHYLUMBELLIFERYL-ALPHA-D-GLUCOPYRANOSIDE HYDRATE
- Synonyms:
-
- 4-METHYLUMBELLIFERYL-ALPHA-D-GLUCOPYRANOSIDE
- 4-METHYLUMBELLIFERYL-ALPHA-D-GLUCOPYRANOSIDE HYDRATE
- 4-METHYLUMBELLIFERYL-ALPHA-D-GLUCOSIDE
- 4-METHYLUMBELLIFERYL A-D-GLUCOPYRANOSIDE
- 4-methyl-2-oxo-2H-chromen-7-yl-α-L-galactopyranoside
- 4-MethyluMbelliferyl α-D-Glucose
- 4-Methyl-7-(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxyMethyl)tetrahydro-2H-pyran-2-yl)oxy)-2H-chroMen-2-one
- 4-MethyluMbellifery -α-D-glucoside
- CAS:
- 17833-43-1
- MF:
- C16H18O8
- MW:
- 338.31
- EINECS:
- 241-794-0
- Product Categories:
-
- substrate
- Substrates
- 13C & 2H Sugars
- Carbohydrates & Derivatives
- Fluorescent Labels & Indicators
- Labeling and Diagnostics Reagents
- Mol File:
- 17833-43-1.mol
4-METHYLUMBELLIFERYL-ALPHA-D-GLUCOPYRANOSIDE HYDRATE Chemical Properties
- Melting point:
- 171-173 °C
- Boiling point:
- 626.9±55.0 °C(Predicted)
- Density
- 1.522±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: 50 mg/mL, clear, colorless to faintly yellow
- pka
- 12.73±0.70(Predicted)
- form
- White solid
- color
- White to Off-White
- BRN
- 1690776
- InChIKey
- YUDPTGPSBJVHCN-JZYAIQKZSA-N
- CAS DataBase Reference
- 17833-43-1(CAS DataBase Reference)
MSDS
- Language:English Provider:SigmaAldrich
- Language:English Provider:ACROS
4-METHYLUMBELLIFERYL-ALPHA-D-GLUCOPYRANOSIDE HYDRATE Usage And Synthesis
Description
4-Methylumbelliferyl-α-D-glucopyranoside is a fluorogenic substrate for α-glucosidase. 4-Methylumbelliferyl-α-D-glucopyranoside is cleaved by α-glucosidase to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high pH (7.12-10.3), respectively, and an emission maximum ranging from 445 to 455 nm, increasing as pH decreases. 4-Methylumbelliferyl-α-D-glucopyranoside has been used to quantify α-glucosidase activity in infant blood spot samples as a biomarker of Fabry and Pompe diseases, lysosomal storage disorders characterized by a deficiency in the enzyme.
Chemical Properties
white to off-white crystalline powder
Uses
4-Methylumbelliferyl α-D-glucopyranoside is used as a flurogenic substrate for the identification, characterization and kinetic analysis of α-D-glucosidase(s).
Uses
4-Methylumbelliferyl-α-D-glucopyranoside is a fluorogenic substrate in the assay of a-glucosidase,it has been used in the study of Pompe disease.
Definition
ChEBI: 4-Methylumbelliferyl-alpha-D-glucopyranoside is a member of coumarins and a glycoside.
Purification Methods
Recrystallise 4-methylumbellifer-7-yl--D-glucopyranoside from hot H2O or EtOH. [Courtin-Duchateau & Veyrière Carbohydr Research 65 23, 29 1978, Beilstein 18 IV 443.]
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