3-AMINO-6-BROMOPYRAZINE-2-CARBONITRILE Chemical Properties

Melting point:

183-184 °C(Solv: benzene (71-43-2))

Boiling point:

341.0±42.0 °C(Predicted)

Density 

1.94±0.1 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

-0.11±0.10(Predicted)

Appearance

Light yellow to yellow Solid

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-41

Safety Statements 

26-39

HS Code 

2933998090

3-AMINO-6-BROMOPYRAZINE-2-CARBONITRILE Usage And Synthesis

Synthesis

Bromine (0.95 mL, 19 mmol) was added slowly and dropwise to a solution of 3-aminopyrazine-2-carbonitrile (1.7 g, 14 mmol) in acetic acid (40 mL) at room temperature. The reaction mixture was heated to 60 °C and held for 30 min, followed by cooling to room temperature. The mixture was poured into ice water and the precipitated solid was collected by filtration. After sufficient washing with water, 3-amino-6-bromopyrazine-2-carbonitrile was obtained as a yellow solid (2.3 g, 83% yield). The product was characterized by 1H NMR (500 MHz, DMSO-d6): δ 8.44 (s, 1H), 7.60 (br s, 2H). Mass spectrum (ES+): m/z 199 (M+H)+.

References

[1] Journal of Organic Chemistry, 1987, vol. 52, # 18, p. 3997 - 4000
[2] Patent: US2007/259876, 2007, A1. Location in patent: Page/Page column 18

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