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OSI-420

Basic information Safety Supplier Related

OSI-420 Basic information

Product Name:
OSI-420
Synonyms:
  • Ethanol, 2-[[4-[(3-ethynylphenyl)aMino]-7-(2-Methoxyethoxy)-6-quinazolinyl]oxy]-, hydrochloride
  • OSI-420 (DesMethyl Erlotinib,CP-473420)
  • CP-473420
  • DesMethyl Erlotinib
  • OSI-420 hydrochloride
  • OSI-420 (DesMethyl Erlotinib)
  • Erlotinib O-DesMethyl Metabolite IsoMer (M14) HCl
  • 6-O-Desmethyl Erlotinib 2
CAS:
183320-51-6
MF:
C21H22ClN3O4
MW:
415.87
EINECS:
200-258-5
Product Categories:
  • Inhibitors
Mol File:
183320-51-6.mol
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OSI-420 Chemical Properties

storage temp. 
Store at -20°C
solubility 
DMSO : 50 mg/mL (120.23 mM; Need ultrasonic)
form 
Powder
color 
White to off-white
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OSI-420 Usage And Synthesis

Uses

OSI 420 can be used in biological study of effects of cytochrome P 450 3A on pharmacokinetic interaction between erlotinib and docetaxel in rats.

Uses

OSI-420 (Desmethyl Erlotinib,CP-473420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor with IC50 of 2 and 20 nM for the inhibition of human EGFR and EGFR autophosphorylation in tumor cells.

target

EGFR

OSI-420Supplier

Chembest Research Laboratories Limited
Tel
+86-21-20908456
Email
sales@BioChemBest.com
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Email
info@chemlin.com.cn
Jinan Trio PharmaTech Co., Ltd.
Tel
+86 (531) 88811783
Email
sales@trio-pharmatech.com (International market)
NCE Biomedical Co.,Ltd.
Tel
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Beijing Comparison Pharmaceutical Technology Co., Ltd
Tel
010-010-52878169 15801002657
Email
sales@bjcomparison.com
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OSI-420(183320-51-6)Related Product Information