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NVP-HSP990(HSP990)

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NVP-HSP990(HSP990) Basic information

Product Name:
NVP-HSP990(HSP990)
Synonyms:
  • CS-786
  • NVP-HSP990(HSP990)
  • HSP-990
  • NVP-HSP990
  • (R)-2-Amino-7-[4-fluoro-2-(6-methoxypyridin-2-yl)phenyl]-4-methyl-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one
  • (7R)-2-amino-7-[4-fluoro-2-(6-methoxy-2-pyridinyl)phenyl]-7,8-dihydro-4-methyl-pyrido[4,3-d]pyrimidin-5(6H)-one
  • HSP990 (NVP-HSP990)
  • (7R)-2-Amino-7-[4-fluoro-2-(6-methoxypyridin-2-yl)phenyl]-4-methyl-7,8-dihydro-6H-pyrido[4,3-d
CAS:
934343-74-5
MF:
C20H18FN5O2
MW:
379.39
Product Categories:
  • Inhibitors
Mol File:
934343-74-5.mol
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NVP-HSP990(HSP990) Chemical Properties

Density 
1.332
storage temp. 
Store at -20°C
solubility 
insoluble in H2O; insoluble in EtOH; ≥12.3 mg/mL in DMSO
form 
solid
color 
Off-white to yellow
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Safety Information

HS Code 
29339900
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NVP-HSP990(HSP990) Usage And Synthesis

Uses

NVP-HSP990 is an orally available HSP90 inhibitor.

Biological Activity

hsp990 (nvp-hsp990) is a potent and selective inhibitor of hsp90 with ic50 values of 0.6, 0.8 and 8.5 nm for hsp90α, hsp90β and grp94, respectively [1].heat shock protein 90 (hsp90) is a chaperone protein that stabilizes proteins against heat stress, assists proteins to fold properly and aids in protein degradation. also, hsp90 stabilizes proteins required for tumor growth.hsp990 (nvp-hsp990) is a potent and selective hsp90 inhibitor. nvp-hsp990 bound to the n-terminal atp-binding domain of hsp90. nvp-hsp990 inhibited trap1 atpase activity by 90% with ic50 value of 320 nm. in gtl-16 cells, nvp-hsp990 destabilized the hsp90-p23 complex in a concentration- and time-dependent way. also, nvp-hsp990 decreased c-met with ec50 value of 37 nm and induced hsp70 with ec50 value of 20 nm. nvp-hsp990 inhibited erk and akt phosphorylation with ec50 values of 11 and 6 nm respectively and thus inhibited erk and akt activation. in five human tumor cell lines, nvp-hsp990 inhibited cell growth with gi50 values of 4-40 nm [1]. in glioma tumor-initiating cells, nvp-hsp990 inhibited cell growth with ic50 value of 10-500 nm in a dose-dependent way and reduced cdk2 and cdk4, thus disrupting cell-cycle control [2].in the gtl-16 gastric cancer mice model, nvp-hsp990 exhibited antitumor efficacy [1].

References

[1]. menezes dl, taverna p, jensen mr, et al. the novel oral hsp90 inhibitor nvp-hsp990 exhibits potent and broad-spectrum antitumor activities in vitro and in vivo. mol cancer ther, 2012, 11(3): 730-739.
[2]. fu j, koul d, yao j, et al. novel hsp90 inhibitor nvp-hsp990 targets cell-cycle regulators to ablate olig2-positive glioma tumor-initiating cells. cancer res, 2013, 73(10): 3062-3074.

NVP-HSP990(HSP990)Supplier

Shanghai Boyle Chemical Co., Ltd.
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Email
sales@boylechem.com
Dalian Meilun Biotech Co., Ltd.
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0411-62910999 13889544652
Email
sales@meilune.com
NCE Biomedical Co.,Ltd.
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4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Haoyuan Chemexpress Co., Ltd.
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021-58950125
Email
info@chemexpress.com
MedChemexpress LLC
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021-58955995
Email
sales@medchemexpress.cn
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